Carbamazepine presents a low incidence of side effects in which the central nervous system is most frequently affected. Reports of involuntary movements in CBZ treatment are rare and often related to toxic levels of CBZ especially in politherapy. The authors report the case of 3 year-old boy with Landau-Kleffner's syndrome. He presented side effects in monotherapy with typical symptomatology correlated to elevated plasma levels. Six months later, following combination with VPA, he had another episode characterized by facial grimaces and involontary movements. Plasma levels of CBZ were never found to be toxic. The authors suggest a pharmacokinetic and a hypothetical receptor-type interaction with VPA.
|Translated title of the contribution||Carbamazepine induced involuntary movements: A case report|
|Number of pages||2|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1990|
ASJC Scopus subject areas
- Clinical Neurology