Carbamazepine plasma and tissue levels in the rat

P. L. Morselli, M. Gerna, S. Garattini

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

A procedure for determining carbamazepine in biological specimens both from animals and humans is described. Carbamazepine was found to enter the brain relatively rapidly and its distribution is uniform through the body. In animals absorption and tissue distribution was found to be influenced to a certain extent by the vehicle employed. A clear correlation between the brain levels and the protection towards maximal electroshock was observed. Preliminary data on humans suggest a relatively slow absorption. An oral dose of 6 mg/kg gives plasma levels comparable to the ones obtained after an administration of 400 mg/kg in rats.

Original languageEnglish
Pages (from-to)2043-2047
Number of pages5
JournalBiochemical Pharmacology
Volume20
Issue number8
DOIs
Publication statusPublished - 1971

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Carbamazepine
Rats
Brain
Animals
Tissue
Plasmas
Electroshock
Tissue Distribution

ASJC Scopus subject areas

  • Pharmacology

Cite this

Carbamazepine plasma and tissue levels in the rat. / Morselli, P. L.; Gerna, M.; Garattini, S.

In: Biochemical Pharmacology, Vol. 20, No. 8, 1971, p. 2043-2047.

Research output: Contribution to journalArticle

Morselli, P. L. ; Gerna, M. ; Garattini, S. / Carbamazepine plasma and tissue levels in the rat. In: Biochemical Pharmacology. 1971 ; Vol. 20, No. 8. pp. 2043-2047.
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