Carbamazepine withdrawal in children with previous symptomatic partial epilepsy: Effects on neuropsychologic function

Daria Riva, Monica Devoti

Research output: Contribution to journalArticlepeer-review

Abstract

Neurocognitive performance was evaluated in seven children with symptomatic partial epilepsy prior to, and at least 12 months after, discontinuation of carbamazepine. The patients treated with carbamazepine monotherapy were seizure-free for at least 2 years and without electroencephalographic anomalies for at least 1 year. Results indicated that carbamazepine at therapeutic levels does not affect intellectual, memory, or attentional functions, or more complex frontal functions. Nevertheless, after therapy withdrawal scores on frontal function tests used in this study improved significantly. This suggests that these functions could have been better without carbamazepine therapy. The fact that carbamazepine decreases neuron membrane excitability and could reduce the information circuity, particularly in the frontal areas, is offered as a possible explanation. Further studies on larger samples using the same design are required to validate these results.

Original languageEnglish
Pages (from-to)357-362
Number of pages6
JournalJournal of Child Neurology
Volume14
Issue number6
Publication statusPublished - Jun 1999

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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