Carbapenem-resistant Enterobacteriaceae Infections in Children: An Italian Retrospective Multicenter Study

Carlotta Montagnani, Manuela Prato, Carlo Scolfaro, Sara Colombo, Susanna Esposito, Claudia Tagliabue, Andrea Lo Vecchio, Eugenia Bruzzese, Anna Loy, Laura Cursi, Marco Vuerich, Maurizio De Martino, Luisa Galli, Italian Society of Pediatric Infectious Diseases

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The spread of carbapenem-resistant Enterobacteriaceae (CRE) is a health problem of major concern. CRE-related infections have significant morbidity and mortality, but data on CRE infection in pediatric population are limited. The aim of this study was to analyze epidemiologic and clinical characteristics, risk factors, therapeutic options and outcome of CRE infections in children in Italy.

METHODS: We performed a retrospective, multicenter, observational study of children with confirmed CRE infection or colonization admitted between January 1, 2011, and March 1, 2014, to 7 Italian pediatric centers.

RESULTS: Sixty-nine patients presenting 74 CRE infections and/or colonization were included. The most frequently isolated strain was Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Children with CRE infections had longer length of stay in hospital (P < 0.001), duration of disease (P = 0.001) and antimicrobial treatment (P < 0.001) than colonized children. Oncologic/immunosuppressive conditions are one of the factors significantly associated with a fatal outcome among children with CRE infections.

CONCLUSIONS: Our study confirms that CRE infections affect mostly children with oncologic diseases and immunosuppression. Controlled studies in large cohorts are needed to evaluate the best therapeutic options and to assess further risk factors influencing outcomes and the survival of pediatric patients with infections caused by CRE.

Original languageEnglish
Pages (from-to)862-8
Number of pages7
JournalPediatric Infectious Disease Journal
Volume35
Issue number8
DOIs
Publication statusPublished - Aug 2016

Fingerprint

Enterobacteriaceae Infections
Carbapenems
Multicenter Studies
Retrospective Studies
Klebsiella pneumoniae
Enterobacteriaceae
Pediatrics
Fatal Outcome
Immunosuppressive Agents
Immunosuppression
Italy
Observational Studies

Keywords

  • Journal Article

Cite this

Carbapenem-resistant Enterobacteriaceae Infections in Children : An Italian Retrospective Multicenter Study. / Montagnani, Carlotta; Prato, Manuela; Scolfaro, Carlo; Colombo, Sara; Esposito, Susanna; Tagliabue, Claudia; Lo Vecchio, Andrea; Bruzzese, Eugenia; Loy, Anna; Cursi, Laura; Vuerich, Marco; De Martino, Maurizio; Galli, Luisa; Italian Society of Pediatric Infectious Diseases.

In: Pediatric Infectious Disease Journal, Vol. 35, No. 8, 08.2016, p. 862-8.

Research output: Contribution to journalArticle

Montagnani, C, Prato, M, Scolfaro, C, Colombo, S, Esposito, S, Tagliabue, C, Lo Vecchio, A, Bruzzese, E, Loy, A, Cursi, L, Vuerich, M, De Martino, M, Galli, L & Italian Society of Pediatric Infectious Diseases 2016, 'Carbapenem-resistant Enterobacteriaceae Infections in Children: An Italian Retrospective Multicenter Study', Pediatric Infectious Disease Journal, vol. 35, no. 8, pp. 862-8. https://doi.org/10.1097/INF.0000000000001188
Montagnani, Carlotta ; Prato, Manuela ; Scolfaro, Carlo ; Colombo, Sara ; Esposito, Susanna ; Tagliabue, Claudia ; Lo Vecchio, Andrea ; Bruzzese, Eugenia ; Loy, Anna ; Cursi, Laura ; Vuerich, Marco ; De Martino, Maurizio ; Galli, Luisa ; Italian Society of Pediatric Infectious Diseases. / Carbapenem-resistant Enterobacteriaceae Infections in Children : An Italian Retrospective Multicenter Study. In: Pediatric Infectious Disease Journal. 2016 ; Vol. 35, No. 8. pp. 862-8.
@article{0f541094ce3f4ed29544f676fe7bf6f8,
title = "Carbapenem-resistant Enterobacteriaceae Infections in Children: An Italian Retrospective Multicenter Study",
abstract = "BACKGROUND: The spread of carbapenem-resistant Enterobacteriaceae (CRE) is a health problem of major concern. CRE-related infections have significant morbidity and mortality, but data on CRE infection in pediatric population are limited. The aim of this study was to analyze epidemiologic and clinical characteristics, risk factors, therapeutic options and outcome of CRE infections in children in Italy.METHODS: We performed a retrospective, multicenter, observational study of children with confirmed CRE infection or colonization admitted between January 1, 2011, and March 1, 2014, to 7 Italian pediatric centers.RESULTS: Sixty-nine patients presenting 74 CRE infections and/or colonization were included. The most frequently isolated strain was Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Children with CRE infections had longer length of stay in hospital (P < 0.001), duration of disease (P = 0.001) and antimicrobial treatment (P < 0.001) than colonized children. Oncologic/immunosuppressive conditions are one of the factors significantly associated with a fatal outcome among children with CRE infections.CONCLUSIONS: Our study confirms that CRE infections affect mostly children with oncologic diseases and immunosuppression. Controlled studies in large cohorts are needed to evaluate the best therapeutic options and to assess further risk factors influencing outcomes and the survival of pediatric patients with infections caused by CRE.",
keywords = "Journal Article",
author = "Carlotta Montagnani and Manuela Prato and Carlo Scolfaro and Sara Colombo and Susanna Esposito and Claudia Tagliabue and {Lo Vecchio}, Andrea and Eugenia Bruzzese and Anna Loy and Laura Cursi and Marco Vuerich and {De Martino}, Maurizio and Luisa Galli and {Italian Society of Pediatric Infectious Diseases}",
year = "2016",
month = "8",
doi = "10.1097/INF.0000000000001188",
language = "English",
volume = "35",
pages = "862--8",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Carbapenem-resistant Enterobacteriaceae Infections in Children

T2 - An Italian Retrospective Multicenter Study

AU - Montagnani, Carlotta

AU - Prato, Manuela

AU - Scolfaro, Carlo

AU - Colombo, Sara

AU - Esposito, Susanna

AU - Tagliabue, Claudia

AU - Lo Vecchio, Andrea

AU - Bruzzese, Eugenia

AU - Loy, Anna

AU - Cursi, Laura

AU - Vuerich, Marco

AU - De Martino, Maurizio

AU - Galli, Luisa

AU - Italian Society of Pediatric Infectious Diseases

PY - 2016/8

Y1 - 2016/8

N2 - BACKGROUND: The spread of carbapenem-resistant Enterobacteriaceae (CRE) is a health problem of major concern. CRE-related infections have significant morbidity and mortality, but data on CRE infection in pediatric population are limited. The aim of this study was to analyze epidemiologic and clinical characteristics, risk factors, therapeutic options and outcome of CRE infections in children in Italy.METHODS: We performed a retrospective, multicenter, observational study of children with confirmed CRE infection or colonization admitted between January 1, 2011, and March 1, 2014, to 7 Italian pediatric centers.RESULTS: Sixty-nine patients presenting 74 CRE infections and/or colonization were included. The most frequently isolated strain was Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Children with CRE infections had longer length of stay in hospital (P < 0.001), duration of disease (P = 0.001) and antimicrobial treatment (P < 0.001) than colonized children. Oncologic/immunosuppressive conditions are one of the factors significantly associated with a fatal outcome among children with CRE infections.CONCLUSIONS: Our study confirms that CRE infections affect mostly children with oncologic diseases and immunosuppression. Controlled studies in large cohorts are needed to evaluate the best therapeutic options and to assess further risk factors influencing outcomes and the survival of pediatric patients with infections caused by CRE.

AB - BACKGROUND: The spread of carbapenem-resistant Enterobacteriaceae (CRE) is a health problem of major concern. CRE-related infections have significant morbidity and mortality, but data on CRE infection in pediatric population are limited. The aim of this study was to analyze epidemiologic and clinical characteristics, risk factors, therapeutic options and outcome of CRE infections in children in Italy.METHODS: We performed a retrospective, multicenter, observational study of children with confirmed CRE infection or colonization admitted between January 1, 2011, and March 1, 2014, to 7 Italian pediatric centers.RESULTS: Sixty-nine patients presenting 74 CRE infections and/or colonization were included. The most frequently isolated strain was Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Children with CRE infections had longer length of stay in hospital (P < 0.001), duration of disease (P = 0.001) and antimicrobial treatment (P < 0.001) than colonized children. Oncologic/immunosuppressive conditions are one of the factors significantly associated with a fatal outcome among children with CRE infections.CONCLUSIONS: Our study confirms that CRE infections affect mostly children with oncologic diseases and immunosuppression. Controlled studies in large cohorts are needed to evaluate the best therapeutic options and to assess further risk factors influencing outcomes and the survival of pediatric patients with infections caused by CRE.

KW - Journal Article

U2 - 10.1097/INF.0000000000001188

DO - 10.1097/INF.0000000000001188

M3 - Article

C2 - 27100130

VL - 35

SP - 862

EP - 868

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 8

ER -