Carbohydrate-functionalized collagen matrices: Design and characterization of a novel neoglycosylated biomaterial

Laura Russo, Alfonso Gautieri, Mario Raspanti, Francesca Taraballi, Francesco Nicotra, Simone Vesentini, Laura Cipolla

Research output: Contribution to journalArticlepeer-review

Abstract

Collagen matrices have been neoglycosylated with lactose by reductive amination at lysine side chains. AFM analysis highlights that the chemical does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalCarbohydrate Research
Volume389
Issue number1
DOIs
Publication statusPublished - May 7 2014

Keywords

  • AFM
  • Collagen
  • Lactose
  • Lectins
  • Neoglycosylation
  • Reductive amination

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Organic Chemistry
  • Medicine(all)

Fingerprint Dive into the research topics of 'Carbohydrate-functionalized collagen matrices: Design and characterization of a novel neoglycosylated biomaterial'. Together they form a unique fingerprint.

Cite this