Carbon Dioxide-enriched Water Inhalation in Patients with Allergic Rhinitis and its Relationship with Nasal Fluid Cytokine/Chemokine Release

Davide Pagani, Emanuela Galliera, Giada Dogliotti, Mario De Bernardi di Valserra, Sara Torretta, Umberto Solimene, Massimiliano M. Corsi, Lorenzo Pignataro

Research output: Contribution to journalArticle

Abstract

Background and Aims: Allergic rhinitis is characterized by eosinophil infiltration and accumulation in the nasal mucosa mainly due to IL-3, IL-5, and eotaxin activities. We undertook this study to investigate a possible in vivo effect of carbon dioxide-enriched water inhalation in patients with allergic rhinitis. Methods: Twenty five consecutive patients inhaled carbon dioxide-enriched water at Fonti di Rabbi Spa Centre (Trento, Italy). Symptom scores for nasal obstruction, itching and sneezing were obtained before and after treatment. Nasal lavage was collected, and IL-3, IL-5, and eotaxin levels were assessed using the quantitative sandwich enzyme immunoassay technique. Cytometric analysis was performed on samples to measure total cell count, CD45+ cells, and percentages of polymorphonucleates and lymphocytes. Results: There were statistically significant differences in chemokine levels and in cell populations between patients and healthy controls before treatment. After carbon dioxide-enriched water inhalation, we observed statistically significant improvements in symptom scores, chemokine levels, and percentages of cell populations. Conclusions: Our results seem to confirm the role of IL-3, IL-5, and eotaxin in the pathophysiology of allergy and the beneficial effect of carbon dioxide-enriched water inhalation in patients affected by allergic rhinitis.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalArchives of Medical Research
Volume42
Issue number4
DOIs
Publication statusPublished - May 2011

Keywords

  • Allergic rhinitis
  • Carbon dioxide-enriched water inhalation
  • Chemokine
  • Cytokine

ASJC Scopus subject areas

  • Medicine(all)

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