Carbon Dioxide-enriched Water Inhalation in Patients with Allergic Rhinitis and its Relationship with Nasal Fluid Cytokine/Chemokine Release

Davide Pagani, Emanuela Galliera, Giada Dogliotti, Mario De Bernardi di Valserra, Sara Torretta, Umberto Solimene, Massimiliano M. Corsi, Lorenzo Pignataro

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background and Aims: Allergic rhinitis is characterized by eosinophil infiltration and accumulation in the nasal mucosa mainly due to IL-3, IL-5, and eotaxin activities. We undertook this study to investigate a possible in vivo effect of carbon dioxide-enriched water inhalation in patients with allergic rhinitis. Methods: Twenty five consecutive patients inhaled carbon dioxide-enriched water at Fonti di Rabbi Spa Centre (Trento, Italy). Symptom scores for nasal obstruction, itching and sneezing were obtained before and after treatment. Nasal lavage was collected, and IL-3, IL-5, and eotaxin levels were assessed using the quantitative sandwich enzyme immunoassay technique. Cytometric analysis was performed on samples to measure total cell count, CD45+ cells, and percentages of polymorphonucleates and lymphocytes. Results: There were statistically significant differences in chemokine levels and in cell populations between patients and healthy controls before treatment. After carbon dioxide-enriched water inhalation, we observed statistically significant improvements in symptom scores, chemokine levels, and percentages of cell populations. Conclusions: Our results seem to confirm the role of IL-3, IL-5, and eotaxin in the pathophysiology of allergy and the beneficial effect of carbon dioxide-enriched water inhalation in patients affected by allergic rhinitis.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalArchives of Medical Research
Volume42
Issue number4
DOIs
Publication statusPublished - May 2011

Fingerprint

Nose
Chemokines
Carbon Dioxide
Inhalation
Interleukin-3
Interleukin-5
Cytokines
Water
Nasal Lavage
Clergy
Sneezing
Nasal Obstruction
Nasal Mucosa
Pruritus
Immunoenzyme Techniques
Eosinophils
Italy
Population
Hypersensitivity
Cell Count

Keywords

  • Allergic rhinitis
  • Carbon dioxide-enriched water inhalation
  • Chemokine
  • Cytokine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Carbon Dioxide-enriched Water Inhalation in Patients with Allergic Rhinitis and its Relationship with Nasal Fluid Cytokine/Chemokine Release. / Pagani, Davide; Galliera, Emanuela; Dogliotti, Giada; De Bernardi di Valserra, Mario; Torretta, Sara; Solimene, Umberto; Corsi, Massimiliano M.; Pignataro, Lorenzo.

In: Archives of Medical Research, Vol. 42, No. 4, 05.2011, p. 329-333.

Research output: Contribution to journalArticle

@article{b3faf057a645422095d8629020bcae0b,
title = "Carbon Dioxide-enriched Water Inhalation in Patients with Allergic Rhinitis and its Relationship with Nasal Fluid Cytokine/Chemokine Release",
abstract = "Background and Aims: Allergic rhinitis is characterized by eosinophil infiltration and accumulation in the nasal mucosa mainly due to IL-3, IL-5, and eotaxin activities. We undertook this study to investigate a possible in vivo effect of carbon dioxide-enriched water inhalation in patients with allergic rhinitis. Methods: Twenty five consecutive patients inhaled carbon dioxide-enriched water at Fonti di Rabbi Spa Centre (Trento, Italy). Symptom scores for nasal obstruction, itching and sneezing were obtained before and after treatment. Nasal lavage was collected, and IL-3, IL-5, and eotaxin levels were assessed using the quantitative sandwich enzyme immunoassay technique. Cytometric analysis was performed on samples to measure total cell count, CD45+ cells, and percentages of polymorphonucleates and lymphocytes. Results: There were statistically significant differences in chemokine levels and in cell populations between patients and healthy controls before treatment. After carbon dioxide-enriched water inhalation, we observed statistically significant improvements in symptom scores, chemokine levels, and percentages of cell populations. Conclusions: Our results seem to confirm the role of IL-3, IL-5, and eotaxin in the pathophysiology of allergy and the beneficial effect of carbon dioxide-enriched water inhalation in patients affected by allergic rhinitis.",
keywords = "Allergic rhinitis, Carbon dioxide-enriched water inhalation, Chemokine, Cytokine",
author = "Davide Pagani and Emanuela Galliera and Giada Dogliotti and {De Bernardi di Valserra}, Mario and Sara Torretta and Umberto Solimene and Corsi, {Massimiliano M.} and Lorenzo Pignataro",
year = "2011",
month = "5",
doi = "10.1016/j.arcmed.2011.07.001",
language = "English",
volume = "42",
pages = "329--333",
journal = "Archives of Medical Research",
issn = "0188-4409",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Carbon Dioxide-enriched Water Inhalation in Patients with Allergic Rhinitis and its Relationship with Nasal Fluid Cytokine/Chemokine Release

AU - Pagani, Davide

AU - Galliera, Emanuela

AU - Dogliotti, Giada

AU - De Bernardi di Valserra, Mario

AU - Torretta, Sara

AU - Solimene, Umberto

AU - Corsi, Massimiliano M.

AU - Pignataro, Lorenzo

PY - 2011/5

Y1 - 2011/5

N2 - Background and Aims: Allergic rhinitis is characterized by eosinophil infiltration and accumulation in the nasal mucosa mainly due to IL-3, IL-5, and eotaxin activities. We undertook this study to investigate a possible in vivo effect of carbon dioxide-enriched water inhalation in patients with allergic rhinitis. Methods: Twenty five consecutive patients inhaled carbon dioxide-enriched water at Fonti di Rabbi Spa Centre (Trento, Italy). Symptom scores for nasal obstruction, itching and sneezing were obtained before and after treatment. Nasal lavage was collected, and IL-3, IL-5, and eotaxin levels were assessed using the quantitative sandwich enzyme immunoassay technique. Cytometric analysis was performed on samples to measure total cell count, CD45+ cells, and percentages of polymorphonucleates and lymphocytes. Results: There were statistically significant differences in chemokine levels and in cell populations between patients and healthy controls before treatment. After carbon dioxide-enriched water inhalation, we observed statistically significant improvements in symptom scores, chemokine levels, and percentages of cell populations. Conclusions: Our results seem to confirm the role of IL-3, IL-5, and eotaxin in the pathophysiology of allergy and the beneficial effect of carbon dioxide-enriched water inhalation in patients affected by allergic rhinitis.

AB - Background and Aims: Allergic rhinitis is characterized by eosinophil infiltration and accumulation in the nasal mucosa mainly due to IL-3, IL-5, and eotaxin activities. We undertook this study to investigate a possible in vivo effect of carbon dioxide-enriched water inhalation in patients with allergic rhinitis. Methods: Twenty five consecutive patients inhaled carbon dioxide-enriched water at Fonti di Rabbi Spa Centre (Trento, Italy). Symptom scores for nasal obstruction, itching and sneezing were obtained before and after treatment. Nasal lavage was collected, and IL-3, IL-5, and eotaxin levels were assessed using the quantitative sandwich enzyme immunoassay technique. Cytometric analysis was performed on samples to measure total cell count, CD45+ cells, and percentages of polymorphonucleates and lymphocytes. Results: There were statistically significant differences in chemokine levels and in cell populations between patients and healthy controls before treatment. After carbon dioxide-enriched water inhalation, we observed statistically significant improvements in symptom scores, chemokine levels, and percentages of cell populations. Conclusions: Our results seem to confirm the role of IL-3, IL-5, and eotaxin in the pathophysiology of allergy and the beneficial effect of carbon dioxide-enriched water inhalation in patients affected by allergic rhinitis.

KW - Allergic rhinitis

KW - Carbon dioxide-enriched water inhalation

KW - Chemokine

KW - Cytokine

UR - http://www.scopus.com/inward/record.url?scp=79961064142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79961064142&partnerID=8YFLogxK

U2 - 10.1016/j.arcmed.2011.07.001

DO - 10.1016/j.arcmed.2011.07.001

M3 - Article

C2 - 21820613

AN - SCOPUS:79961064142

VL - 42

SP - 329

EP - 333

JO - Archives of Medical Research

JF - Archives of Medical Research

SN - 0188-4409

IS - 4

ER -