Carbon dioxide-induced panic attacks and quantitative electroencephalogram in panic disorder patients

Fabiana L. Lopes, Mariana M. Oliveira, Rafael C. Freire, Daniela Caldirola, Giampaolo Perna, Laura Bellodi, Alexandre M. Valença, Isabella Nascimento, Roberto A. Piedade, Pedro Ribeiro, Walter A. Zin, Antonio E. Nardi

Research output: Contribution to journalArticle

Abstract

The objective of the study was to investigate and compare the brain cortical activity, as indexed by quantitative electroencephalographic (qEEG) power, coherence and asymmetry measures, in panic disorder (PD) patients during an induced panic attack with a 35% CO2 challenge test and also in a resting condition. Fifteen subjects with PD were randomly assigned to both 35% CO2 mixture and atmospheric compressed air, in a double-blind study design, with EEG being recorded for a 20-min period. During induced panic attacks we found a reduced right-sided frontal orbital asymmetry in the beta band, a decreased occipital frontal intra-hemispheric coherence in the delta band at both right and left sides, a left-sided occipital delta inter-hemispheric asymmetry and an increased relative power in the beta wave at T4. Our data showed a disturbed frontal cortical processing, pointing to an imbalance of the frontal and occipital sites, common to both hemispheres, and an increased right posterior activity related to the high arousing panic attack condition. Those findings corroborate the Neuroanatomical hypothesis of PD.

Original languageEnglish
Pages (from-to)357-363
Number of pages7
JournalWorld Journal of Biological Psychiatry
Volume11
Issue number2 PART 2
DOIs
Publication statusPublished - 2010

Fingerprint

Panic Disorder
Carbon Dioxide
Electroencephalography
Compressed Air
Double-Blind Method
Brain

Keywords

  • Anxiety
  • Asymmetry
  • Coherence
  • Neuroimaging
  • Panicogenic challenge

ASJC Scopus subject areas

  • Biological Psychiatry
  • Psychiatry and Mental health

Cite this

Lopes, F. L., Oliveira, M. M., Freire, R. C., Caldirola, D., Perna, G., Bellodi, L., ... Nardi, A. E. (2010). Carbon dioxide-induced panic attacks and quantitative electroencephalogram in panic disorder patients. World Journal of Biological Psychiatry, 11(2 PART 2), 357-363. https://doi.org/10.3109/15622970903144012

Carbon dioxide-induced panic attacks and quantitative electroencephalogram in panic disorder patients. / Lopes, Fabiana L.; Oliveira, Mariana M.; Freire, Rafael C.; Caldirola, Daniela; Perna, Giampaolo; Bellodi, Laura; Valença, Alexandre M.; Nascimento, Isabella; Piedade, Roberto A.; Ribeiro, Pedro; Zin, Walter A.; Nardi, Antonio E.

In: World Journal of Biological Psychiatry, Vol. 11, No. 2 PART 2, 2010, p. 357-363.

Research output: Contribution to journalArticle

Lopes, FL, Oliveira, MM, Freire, RC, Caldirola, D, Perna, G, Bellodi, L, Valença, AM, Nascimento, I, Piedade, RA, Ribeiro, P, Zin, WA & Nardi, AE 2010, 'Carbon dioxide-induced panic attacks and quantitative electroencephalogram in panic disorder patients', World Journal of Biological Psychiatry, vol. 11, no. 2 PART 2, pp. 357-363. https://doi.org/10.3109/15622970903144012
Lopes, Fabiana L. ; Oliveira, Mariana M. ; Freire, Rafael C. ; Caldirola, Daniela ; Perna, Giampaolo ; Bellodi, Laura ; Valença, Alexandre M. ; Nascimento, Isabella ; Piedade, Roberto A. ; Ribeiro, Pedro ; Zin, Walter A. ; Nardi, Antonio E. / Carbon dioxide-induced panic attacks and quantitative electroencephalogram in panic disorder patients. In: World Journal of Biological Psychiatry. 2010 ; Vol. 11, No. 2 PART 2. pp. 357-363.
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