Abstract
The objective of the study was to investigate and compare the brain cortical activity, as indexed by quantitative electroencephalographic (qEEG) power, coherence and asymmetry measures, in panic disorder (PD) patients during an induced panic attack with a 35% CO2 challenge test and also in a resting condition. Fifteen subjects with PD were randomly assigned to both 35% CO2 mixture and atmospheric compressed air, in a double-blind study design, with EEG being recorded for a 20-min period. During induced panic attacks we found a reduced right-sided frontal orbital asymmetry in the beta band, a decreased occipital frontal intra-hemispheric coherence in the delta band at both right and left sides, a left-sided occipital delta inter-hemispheric asymmetry and an increased relative power in the beta wave at T4. Our data showed a disturbed frontal cortical processing, pointing to an imbalance of the frontal and occipital sites, common to both hemispheres, and an increased right posterior activity related to the high arousing panic attack condition. Those findings corroborate the Neuroanatomical hypothesis of PD.
| Original language | English |
|---|---|
| Pages (from-to) | 357-363 |
| Number of pages | 7 |
| Journal | World Journal of Biological Psychiatry |
| Volume | 11 |
| Issue number | 2 PART 2 |
| DOIs | |
| Publication status | Published - 2010 |
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Keywords
- Anxiety
- Asymmetry
- Coherence
- Neuroimaging
- Panicogenic challenge
ASJC Scopus subject areas
- Biological Psychiatry
- Psychiatry and Mental health
Cite this
Carbon dioxide-induced panic attacks and quantitative electroencephalogram in panic disorder patients. / Lopes, Fabiana L.; Oliveira, Mariana M.; Freire, Rafael C.; Caldirola, Daniela; Perna, Giampaolo; Bellodi, Laura; Valença, Alexandre M.; Nascimento, Isabella; Piedade, Roberto A.; Ribeiro, Pedro; Zin, Walter A.; Nardi, Antonio E.
In: World Journal of Biological Psychiatry, Vol. 11, No. 2 PART 2, 2010, p. 357-363.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Carbon dioxide-induced panic attacks and quantitative electroencephalogram in panic disorder patients
AU - Lopes, Fabiana L.
AU - Oliveira, Mariana M.
AU - Freire, Rafael C.
AU - Caldirola, Daniela
AU - Perna, Giampaolo
AU - Bellodi, Laura
AU - Valença, Alexandre M.
AU - Nascimento, Isabella
AU - Piedade, Roberto A.
AU - Ribeiro, Pedro
AU - Zin, Walter A.
AU - Nardi, Antonio E.
PY - 2010
Y1 - 2010
N2 - The objective of the study was to investigate and compare the brain cortical activity, as indexed by quantitative electroencephalographic (qEEG) power, coherence and asymmetry measures, in panic disorder (PD) patients during an induced panic attack with a 35% CO2 challenge test and also in a resting condition. Fifteen subjects with PD were randomly assigned to both 35% CO2 mixture and atmospheric compressed air, in a double-blind study design, with EEG being recorded for a 20-min period. During induced panic attacks we found a reduced right-sided frontal orbital asymmetry in the beta band, a decreased occipital frontal intra-hemispheric coherence in the delta band at both right and left sides, a left-sided occipital delta inter-hemispheric asymmetry and an increased relative power in the beta wave at T4. Our data showed a disturbed frontal cortical processing, pointing to an imbalance of the frontal and occipital sites, common to both hemispheres, and an increased right posterior activity related to the high arousing panic attack condition. Those findings corroborate the Neuroanatomical hypothesis of PD.
AB - The objective of the study was to investigate and compare the brain cortical activity, as indexed by quantitative electroencephalographic (qEEG) power, coherence and asymmetry measures, in panic disorder (PD) patients during an induced panic attack with a 35% CO2 challenge test and also in a resting condition. Fifteen subjects with PD were randomly assigned to both 35% CO2 mixture and atmospheric compressed air, in a double-blind study design, with EEG being recorded for a 20-min period. During induced panic attacks we found a reduced right-sided frontal orbital asymmetry in the beta band, a decreased occipital frontal intra-hemispheric coherence in the delta band at both right and left sides, a left-sided occipital delta inter-hemispheric asymmetry and an increased relative power in the beta wave at T4. Our data showed a disturbed frontal cortical processing, pointing to an imbalance of the frontal and occipital sites, common to both hemispheres, and an increased right posterior activity related to the high arousing panic attack condition. Those findings corroborate the Neuroanatomical hypothesis of PD.
KW - Anxiety
KW - Asymmetry
KW - Coherence
KW - Neuroimaging
KW - Panicogenic challenge
UR - http://www.scopus.com/inward/record.url?scp=77950852362&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950852362&partnerID=8YFLogxK
U2 - 10.3109/15622970903144012
DO - 10.3109/15622970903144012
M3 - Article
C2 - 19958206
AN - SCOPUS:77950852362
VL - 11
SP - 357
EP - 363
JO - World Journal of Biological Psychiatry
JF - World Journal of Biological Psychiatry
SN - 1562-2975
IS - 2 PART 2
ER -