Carbon dioxide production during cardiopulmonary bypass: Pathophysiology, measure and clinical relevance

Marco Ranucci, Giovanni Carboni, Mauro Cotza, Filip De Somer

Research output: Contribution to journalReview article

Abstract

Carbon dioxide production during cardiopulmonary bypass derives from both the aerobic metabolism and the buffering of lactic acid produced by tissues under anaerobic conditions. Therefore, carbon dioxide removal monitoring is an important measure of the adequacy of perfusion and oxygen delivery. However, routine monitoring of carbon dioxide removal is not widely applied. The present article reviews the main physiological and pathophysiological sources of carbon dioxide, the available techniques to assess carbon dioxide production and removal and the clinically relevant applications of carbon dioxide-related variables as markers of the adequacy of perfusion during cardiopulmonary bypass.

Original languageEnglish
Pages (from-to)4-12
Number of pages9
JournalPerfusion (United Kingdom)
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • blood lactates
  • capnography
  • carbon dioxide
  • cardiopulmonary bypass
  • oxygen delivery

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Safety Research
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

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