Carboplatin, cisplatin and paclitaxel in the treatment of patients with epithelial ovarian cancer

S. De Placido, S. Tramontana, E. Ferrari, A. De Matteis, R. Lauria, F. Perrone, A. R. Bianco, C. Gallo, P. Ricchi, G. De Placido, S. Pignata, R. De Vivo, P. Silvestro, G. Landi, F. Nuzzo, G. Casella, F. Iodice, F. Tramontana, E. Varriale, A. V. LombardiR. Costanzo

Research output: Contribution to journalArticle

Abstract

Background: Prognosis of advanced ovarian cancer is unsatisfactory. Chemotherapy can be intensified combining active drugs at their highest possible doses. Patients and Methods. In this phase I/II trial, 77 untreated patients received escalating doses of paclitaxel (135, 155, 175, 195 and 215 mg/m2, infused over 3 hours) with carboplatin (AUC 3.6) and cisplatin (60 mg/m2). Nine, 16, 13, 8 and 3 patients were treated at the five levels, respectively. A further 28 patients were treated at the maximum tolerable dose (MTD). Results: Dose-limiting toxicities (one WHO grade 3 constipation, one grade 2 prolonged peripheral neurotoxicity and one grade 3 cardiac toxicity) occurred at 215 mg/m2 in 3 out of 3 patients. MTD was reached at level 4 paclitaxel dose (195 mg/m2). Response was evaluated in 62 patients. A complete response was achieved in 23 patients (37.1% - 95% CI 25.2-50.3), including 16 (25.8%) pathological and partial response in 28 (45.2%), for an overall response rate of 82.3% (95% exact CL: 70.5%-90.8%). The probability of response was affected by the degree of initial debulking (p=0.002) and not by the paclitaxel dose. In patients with stage III-IV disease, median progression-free survival was 17 months (95% CI 14-25). After a median follow-up of 28 months, median survival had not been reached; 2-year estimated survival was 67%. Conclusion: Paclitaxel can be safely given at the dose of 195 mg/m2 in combination with carboplatin (AUC 3.6) and cisplatin (60 mg/m2). This combination is active and safe and could be considered in clinical settings requiring intensive short treatment.

Original languageEnglish
Pages (from-to)4023-4030
Number of pages8
JournalAnticancer Research
Volume20
Issue number5 C
Publication statusPublished - 2000

Keywords

  • Carboplatin
  • Chemotherapy
  • Cisplatin
  • Ovarian cancer
  • Paclitaxel

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    De Placido, S., Tramontana, S., Ferrari, E., De Matteis, A., Lauria, R., Perrone, F., Bianco, A. R., Gallo, C., Ricchi, P., De Placido, G., Pignata, S., De Vivo, R., Silvestro, P., Landi, G., Nuzzo, F., Casella, G., Iodice, F., Tramontana, F., Varriale, E., ... Costanzo, R. (2000). Carboplatin, cisplatin and paclitaxel in the treatment of patients with epithelial ovarian cancer. Anticancer Research, 20(5 C), 4023-4030.