Abstract
Aims: Carboplatin plus etoposide has modest efficacy in docetaxel-pretreated castration-resistant prostate cancer patients. We hypothesized that carboplatin-etoposide could still exert some therapeutic activity after docetaxel, cabazitaxel and either abiraterone or enzalutamide. Patients & methods: We enrolled 15 patients in the first step of a Phase II trial. The target sample size is 46 patients. The primary end point of the study was progression-free survival after 12 weeks. Results: The median progression-free survival was 11 weeks (range: 8-18), while median overall survival was 18 weeks (range: 12-26). Of seven patients with measurable disease, two had a partial response, two showed stable disease and the remaining three had progressive disease as the best radiological response. Five patients were considered progression-free after 12 weeks, prompting continuation of the trial. Conclusion: Our preliminary findings support the hypothesis that carboplatin plus etoposide may yield some clinical benefit in a population of patients who failed all currently approved therapeutic options for prostate cancer.
Original language | English |
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Pages (from-to) | 1353-1360 |
Number of pages | 8 |
Journal | Future Oncology |
Volume | 10 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- abiraterone
- carboplatin
- enzalutamide
- etoposide
- neuroendocrine
- prostate cancer
ASJC Scopus subject areas
- Oncology
- Cancer Research
- Medicine(all)