Carboplatin plus oral etoposide in elderly patients with advanced non small cell lung cancer. A phase II study

C. Gridelli, A. Rossi, F. Scognamiglio, C. Guida, F. Fiore, T. Gatani, G. Scoppa, M. Pergola

Research output: Contribution to journalArticlepeer-review

Abstract

More than 30% of lung cancers arise in patients over 70 years old. Elderly patients are not considered to tolerate chemotherapy, are generally excluded from clinical trials, and are not considered eligible for aggressive cisplatinbased chemotherapy in clinical practice. The aims of the present study were to test the activity and toxicity of a combination of carboplatin and oral etoposide in patients over 70 years old with advanced non small cell lung cancer. Carboplatin was given at a dose of 300 mg/m2, i.v., at day 1, and oral etoposide (50 mg capsules) at a total dose of l 00 mg/die from day 1 to day 7, recycled every 4 week. Fourteen patients entered the study. Median age was 73 years (range 70-77), 42.9% of patients had at least one concomitant illness. The trial, according to the Gehan design, was terrninated earlier because no objective response was observed among the first 14 patients. We reported, according to intent to treat analysis, 2 stable and 12 progressive diseases. Median time to progression was 2 months and median survival 6 months. Remarkable hematological toxicity was recorded. Finally, we do not recommend the combination of carboplatin and oral etoposide, at the doses and schedule used in the present study, in the treatment of elderly patients with advanced NSCLC. The combination might be reconsidered using a different etoposide schedule with chronic administration (21 days).

Original languageEnglish
Pages (from-to)4755-4758
Number of pages4
JournalAnticancer Research
Volume17
Issue number6 D
Publication statusPublished - Nov 1997

Keywords

  • Carboplatin
  • Chemotherapy
  • Elderly patients
  • Non small cell lung cancer
  • Oral etoposide

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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