Carboxyethyl γ - Aminobutyric Acid, a polyamine derivative, improves the recovery of EBV-transformed lymphocytes

Antonella Cerino, Marco Bestagno, Marco Colonna, Fernando Fussi, Giulia C B Astaldi Ricotti

Research output: Contribution to journalArticlepeer-review

Abstract

A polyamine derivative, carboxyethyl - Aminobutyric Acid (CEGABA), induces the formation of a large number of Epstein-Barr Virus (EBV) transformed lymphocytes, when added to the culture medium immediately after EBV infection. However, CEGABA shows only a moderate effect on the stability of EBV-transformed cell lines over time, and does not affect the growth of stabilized cell lines. It is possible that CEGABA acts on cells other than EBV transformed lymphocytes (in fact, after EBV infection all types of mononuclear cells from the blood are present in the culture) and indirectly promotes the growth of EBV transformed lymphocytes.

Original languageEnglish
Pages (from-to)931-936
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume150
Issue number3
DOIs
Publication statusPublished - Feb 15 1988

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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