Carboxyl-terminal parathyroid hormone fragments: biologic effects.

A. Scillitani, V. Guarnieri, C. Battista, I. Chiodini, A. S. Salcuni, S. Minisola, C. M. Francucci, V. Carnevale

Research output: Contribution to journalArticlepeer-review

Abstract

Carboxyl-terminal PTH fragments (C-PTH), are generated by both direct secretion from parathyroids in relation to serum calcium levels and catabolism of PTH operated by the Kupffer cells in the liver. These molecular fragments have been till recently regarded as inert byproducts of PTH metabolism, since they do not interact with the PTH/PTH-related peptide (rP) receptor, which mediates the classical hormone actions. Current findings instead indicate that C-PTH would interact with a putative C-PTH receptor. This way, C-PTH seem to exert specific effects on calcium homeostasis and bone metabolism, opposite to those of the synthetic agonist of PTH/PTHrP receptor (i.e. PTH 1-34). In vitro and in vivo data actually indicate that C-PTH, by interacting with specific receptors, could have an anti-calcemic action, as well as a pro-apoptotic effect on both osteocytes and osteoclasts. This in turn could result in a reduced activity of the latter cells, with a consequent inhibition of bone resorption.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalJournal of Endocrinological Investigation
Volume34
Issue number7 Suppl
Publication statusPublished - Jul 2011

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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