Carcinogen-DNA adducts in human alveolar macrophages

A. Izzotti, M. Bagnasco, G. A. Rossi, S. De Flora

Research output: Contribution to journalArticlepeer-review

Abstract

The occurrence of 7β, 8α-dihydroxy-(9α, 10α)-epoxy-7.8, 9, 10- tetrahydrben-zo(a)pyrene (BPDE-)-DNA adducts was investigated by synchronous fluorescence spectrophotometry in human pulmonary alveolar macrophages (PAM) collected by bronchoalveolar lavage. In preliminary assays BPDE-DNA adducts were consistently detected in PAM of smokers, whereas samples from nonsmokcrs did not exhibit specific peaks.

Original languageEnglish
Pages (from-to)33-34
Number of pages2
JournalRespiration
Volume59
DOIs
Publication statusPublished - 1992

Keywords

  • Bronchoalveolar lavage
  • Carcinogen-DNA adducts
  • Cigarette smoke
  • Human monitoring
  • Pulmonary alveolar macrophages
  • Synchronous fluorescence Spectrophotometry

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

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