Abstract
The relative resistance of liver cells in primary monolayer cell culture to the cytocidal effects of methotrexate, Adriamycin, cycloheximide, or aflatoxin B1 was studied using cells derived from normal rats, rats subjected to to-thirds hepatectomy, or rats fed dietary carcinogen. Normal rat liver cells were highly sensitive to the toxic effects of methotrexate, Adriamycin, cycloheximide, and aflatoxin B1. In contrast, liver cells from carcinogen-treated rats were resistant to the toxic effects of these agents. Cells derived from rats at 24 hr post two-thirds hepatectomy were sensitive to Adriamycin but not to cycloheximide or aflatoxin B1.
| Original language | English |
|---|---|
| Pages (from-to) | 1715-1719 |
| Number of pages | 5 |
| Journal | Cancer Research |
| Volume | 41 |
| Issue number | 5 |
| Publication status | Published - 1981 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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Carcinogen-induced drug resistance in rat hepatocytes. / Carr, B. I.; Laishes, B. A.
In: Cancer Research, Vol. 41, No. 5, 1981, p. 1715-1719.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Carcinogen-induced drug resistance in rat hepatocytes
AU - Carr, B. I.
AU - Laishes, B. A.
PY - 1981
Y1 - 1981
N2 - The relative resistance of liver cells in primary monolayer cell culture to the cytocidal effects of methotrexate, Adriamycin, cycloheximide, or aflatoxin B1 was studied using cells derived from normal rats, rats subjected to to-thirds hepatectomy, or rats fed dietary carcinogen. Normal rat liver cells were highly sensitive to the toxic effects of methotrexate, Adriamycin, cycloheximide, and aflatoxin B1. In contrast, liver cells from carcinogen-treated rats were resistant to the toxic effects of these agents. Cells derived from rats at 24 hr post two-thirds hepatectomy were sensitive to Adriamycin but not to cycloheximide or aflatoxin B1.
AB - The relative resistance of liver cells in primary monolayer cell culture to the cytocidal effects of methotrexate, Adriamycin, cycloheximide, or aflatoxin B1 was studied using cells derived from normal rats, rats subjected to to-thirds hepatectomy, or rats fed dietary carcinogen. Normal rat liver cells were highly sensitive to the toxic effects of methotrexate, Adriamycin, cycloheximide, and aflatoxin B1. In contrast, liver cells from carcinogen-treated rats were resistant to the toxic effects of these agents. Cells derived from rats at 24 hr post two-thirds hepatectomy were sensitive to Adriamycin but not to cycloheximide or aflatoxin B1.
UR - http://www.scopus.com/inward/record.url?scp=0019449331&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019449331&partnerID=8YFLogxK
M3 - Article
C2 - 6783299
AN - SCOPUS:0019449331
VL - 41
SP - 1715
EP - 1719
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 5
ER -