Carcinogen-induced drug resistance in rat hepatocytes

B. I. Carr, B. A. Laishes

Research output: Contribution to journalArticlepeer-review


The relative resistance of liver cells in primary monolayer cell culture to the cytocidal effects of methotrexate, Adriamycin, cycloheximide, or aflatoxin B1 was studied using cells derived from normal rats, rats subjected to to-thirds hepatectomy, or rats fed dietary carcinogen. Normal rat liver cells were highly sensitive to the toxic effects of methotrexate, Adriamycin, cycloheximide, and aflatoxin B1. In contrast, liver cells from carcinogen-treated rats were resistant to the toxic effects of these agents. Cells derived from rats at 24 hr post two-thirds hepatectomy were sensitive to Adriamycin but not to cycloheximide or aflatoxin B1.

Original languageEnglish
Pages (from-to)1715-1719
Number of pages5
JournalCancer Research
Issue number5
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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