Carcinogenesis and metastasis in liver: Cell physiological basis

Anna Rossetto, Valli De Re, Agostino Steffan, Matteo Ravaioli, Gianmaria Miolo, Patrizia Leone, Vito Racanelli, Alessandro Uzzau, Umberto Baccarani, Matteo Cescon

Research output: Contribution to journalReview article

Abstract

Hepatocellular carcinoma (HCC) incidence is rising. This paper summarises the current state of knowledge and recent discoveries in the cellular and physiological mechanisms leading to the development of liver cancer, especially HCC, and liver metastases. After reviewing normal hepatic cytoarchitecture and immunological characteristics, the paper addresses the pathophysiological factors that cause liver damage and predispose to neoplasia. Particular attention is given to chronic liver diseases, metabolic syndrome and the impact of altered gut microbiota, disrupted circadian rhythm and psychological stress. Improved knowledge of the multifactorial aetiology of HCC has important implications for the prevention and treatment of this cancer and of liver metastases in general.

Original languageEnglish
Article number1731
Number of pages16
JournalCancers
Volume11
Issue number11
DOIs
Publication statusPublished - Nov 2019

Keywords

  • Circadian homeostasis
  • Cortisol
  • Hepatic stellate cells
  • Hepatocellular carcinoma
  • Immunity
  • Myofibroblasts
  • Nonalcoholic fatty liver disease
  • Nonalcoholic steatohepatitis
  • VEGF

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Rossetto, A., De Re, V., Steffan, A., Ravaioli, M., Miolo, G., Leone, P., Racanelli, V., Uzzau, A., Baccarani, U., & Cescon, M. (2019). Carcinogenesis and metastasis in liver: Cell physiological basis. Cancers, 11(11), [1731]. https://doi.org/10.3390/cancers11111731