Carcinogenicity study of 3-(5-nitro-2-furyl)-imidazo (1,2-α) pyridine in mice and rats

J. R. Cabral, L. Rossi, T. A. Dragani, G. Della Porta

Research output: Contribution to journalArticlepeer-review

Abstract

3-(5-nitro-2-furyl)-imidazo (1,2-α) pyridine was tested for carcinogenicity by long-term administration in the diet of CTM mice at 0.1, 0.2 and 0.4% dose levels and of Wistar rats at 0.2 and 0.4% dose levels, and by short-term intraperitoneal injections to suckling BALB/c mice. The compound was a strong carcinogen. In CTM mice it induced carcinomas of the esophagus and forestomach at all dose levels and thymic lymphosarcomas at the two highest doses. In male and female rats, esophagus and forestomach papillomas were observed at all dose levels, whereas esophagus and forestomach carcinomas and kidney tumors were observed only at the high dose. In female rats, an increased incidence of mammary tumors was seen at the high dose. The treatment of BALB/c suckling mice by intraperitoneal injections did not induce a clear carcinogenic response.

Original languageEnglish
Pages (from-to)131-144
Number of pages14
JournalTumori
Volume66
Issue number2
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Cancer Research

Fingerprint Dive into the research topics of 'Carcinogenicity study of 3-(5-nitro-2-furyl)-imidazo (1,2-α) pyridine in mice and rats'. Together they form a unique fingerprint.

Cite this