Carcinoma of the larynx in the elderly: Analysis of potentially significant prognostic variables

M. Magnano, A. De Stefani, A. Usai, W. Lerda, R. Albera, R. Ragona, M. Bussi, M. Airoldi, G. Cortesina

Research output: Contribution to journalArticlepeer-review


The incidence reported for carcinomas of the head and neck currently peaks between the sixth and seventh decades of life. In this retrospective study we were interested in learning whether age is a potentially significant prognostic factor for survival. We considered a set of variables in a series of 134 patients, divided into two groups; between 65 and 70 years of age, and older than 70. Stage I-II tumors were present in 44 patients, while locally advanced lesions (stages III-IV) were present in 90. Statistical analysis of survival was performed using the actuarial survival rates according to Kaplan-Meier; significance was evaluated using the log-rank test. Multivariate analysis was performed according to the Cox logistic regression model to determine the prognostic significance of any of the variables. Univariate analysis was performed on a series of variables regarding the patient, tumor and treatment. In the younger group, age appeared to be a favorable prognostic factor. Tumor size had a significant effect on disease- free survival, both globally and between the two groups (p

Original languageEnglish
Pages (from-to)316-322
Number of pages7
JournalAging clinical and experimental research
Issue number5
Publication statusPublished - Oct 1999


  • Elderly
  • Larynx
  • Neoplasms
  • Prognostic factors
  • Treatment

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology


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