Abstract
Sebaceous neoplasms, including carcinoma, can exceptionally arise in extracutaneous sites. We present the third known case of carcinoma with sebaceous differentiation in the uterine cervix. Histologic and immunohistochemical features suggested a metaplastic process within an otherwise usual squamous cell carcinoma. We speculate that, by analogy with the skin where the epidermis and the 3 types of adnexa have a common embryologic origin from basal cell layer of the superficial ectoderm, it is possible that endocervical reserve cells, in addition to the well-known capacity of squamous differentiation, retain the potential to give rise to appendages including sebaceous glands.
| Original language | English |
|---|---|
| Pages (from-to) | 292-295 |
| Number of pages | 4 |
| Journal | International Journal of Gynecological Pathology |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2009 |
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Keywords
- Extracutaneous
- Sebaceous carcinoma
- Sebaceous differentiation
- Squamous cell carcinoma
- Uterine cervix
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Obstetrics and Gynaecology
Cite this
Carcinoma of the uterine cervix with squamous and sebaceous differentiation. / Rizzardi, Clara; Perin, Tiziana; Schneider, Manuela; Rossi, Diego; Brollo, Alessandro; Melato, Mauro; Canzonieri, Vincenzo.
In: International Journal of Gynecological Pathology, Vol. 28, No. 3, 05.2009, p. 292-295.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Carcinoma of the uterine cervix with squamous and sebaceous differentiation
AU - Rizzardi, Clara
AU - Perin, Tiziana
AU - Schneider, Manuela
AU - Rossi, Diego
AU - Brollo, Alessandro
AU - Melato, Mauro
AU - Canzonieri, Vincenzo
PY - 2009/5
Y1 - 2009/5
N2 - Sebaceous neoplasms, including carcinoma, can exceptionally arise in extracutaneous sites. We present the third known case of carcinoma with sebaceous differentiation in the uterine cervix. Histologic and immunohistochemical features suggested a metaplastic process within an otherwise usual squamous cell carcinoma. We speculate that, by analogy with the skin where the epidermis and the 3 types of adnexa have a common embryologic origin from basal cell layer of the superficial ectoderm, it is possible that endocervical reserve cells, in addition to the well-known capacity of squamous differentiation, retain the potential to give rise to appendages including sebaceous glands.
AB - Sebaceous neoplasms, including carcinoma, can exceptionally arise in extracutaneous sites. We present the third known case of carcinoma with sebaceous differentiation in the uterine cervix. Histologic and immunohistochemical features suggested a metaplastic process within an otherwise usual squamous cell carcinoma. We speculate that, by analogy with the skin where the epidermis and the 3 types of adnexa have a common embryologic origin from basal cell layer of the superficial ectoderm, it is possible that endocervical reserve cells, in addition to the well-known capacity of squamous differentiation, retain the potential to give rise to appendages including sebaceous glands.
KW - Extracutaneous
KW - Sebaceous carcinoma
KW - Sebaceous differentiation
KW - Squamous cell carcinoma
KW - Uterine cervix
UR - http://www.scopus.com/inward/record.url?scp=69049105354&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69049105354&partnerID=8YFLogxK
U2 - 10.1097/PGP.0b013e31818d10be
DO - 10.1097/PGP.0b013e31818d10be
M3 - Article
VL - 28
SP - 292
EP - 295
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
SN - 0277-1691
IS - 3
ER -