TY - JOUR
T1 - Carcinoma of the uterine cervix with squamous and sebaceous differentiation
AU - Rizzardi, Clara
AU - Perin, Tiziana
AU - Schneider, Manuela
AU - Rossi, Diego
AU - Brollo, Alessandro
AU - Melato, Mauro
AU - Canzonieri, Vincenzo
PY - 2009/5
Y1 - 2009/5
N2 - Sebaceous neoplasms, including carcinoma, can exceptionally arise in extracutaneous sites. We present the third known case of carcinoma with sebaceous differentiation in the uterine cervix. Histologic and immunohistochemical features suggested a metaplastic process within an otherwise usual squamous cell carcinoma. We speculate that, by analogy with the skin where the epidermis and the 3 types of adnexa have a common embryologic origin from basal cell layer of the superficial ectoderm, it is possible that endocervical reserve cells, in addition to the well-known capacity of squamous differentiation, retain the potential to give rise to appendages including sebaceous glands.
AB - Sebaceous neoplasms, including carcinoma, can exceptionally arise in extracutaneous sites. We present the third known case of carcinoma with sebaceous differentiation in the uterine cervix. Histologic and immunohistochemical features suggested a metaplastic process within an otherwise usual squamous cell carcinoma. We speculate that, by analogy with the skin where the epidermis and the 3 types of adnexa have a common embryologic origin from basal cell layer of the superficial ectoderm, it is possible that endocervical reserve cells, in addition to the well-known capacity of squamous differentiation, retain the potential to give rise to appendages including sebaceous glands.
KW - Extracutaneous
KW - Sebaceous carcinoma
KW - Sebaceous differentiation
KW - Squamous cell carcinoma
KW - Uterine cervix
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UR - http://www.scopus.com/inward/citedby.url?scp=69049105354&partnerID=8YFLogxK
U2 - 10.1097/PGP.0b013e31818d10be
DO - 10.1097/PGP.0b013e31818d10be
M3 - Article
C2 - 19620949
AN - SCOPUS:69049105354
VL - 28
SP - 292
EP - 295
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
SN - 0277-1691
IS - 3
ER -