Carcinoma of the uterine cervix with squamous and sebaceous differentiation

Clara Rizzardi, Tiziana Perin, Manuela Schneider, Diego Rossi, Alessandro Brollo, Mauro Melato, Vincenzo Canzonieri

Research output: Contribution to journalArticlepeer-review


Sebaceous neoplasms, including carcinoma, can exceptionally arise in extracutaneous sites. We present the third known case of carcinoma with sebaceous differentiation in the uterine cervix. Histologic and immunohistochemical features suggested a metaplastic process within an otherwise usual squamous cell carcinoma. We speculate that, by analogy with the skin where the epidermis and the 3 types of adnexa have a common embryologic origin from basal cell layer of the superficial ectoderm, it is possible that endocervical reserve cells, in addition to the well-known capacity of squamous differentiation, retain the potential to give rise to appendages including sebaceous glands.

Original languageEnglish
Pages (from-to)292-295
Number of pages4
JournalInternational Journal of Gynecological Pathology
Issue number3
Publication statusPublished - May 2009


  • Extracutaneous
  • Sebaceous carcinoma
  • Sebaceous differentiation
  • Squamous cell carcinoma
  • Uterine cervix

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology


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