Carcinosarcoma of the prostate: Case report with molecular and histological characterization

Samanta Salvi, Valentina Casadio, Filippo Martignano, Giorgia Gurioli, Maria Maddalena Tumedei, Daniele Calistri, Roberta Gunelli, Matteo Costantini

Research output: Contribution to journalArticle

Abstract

Background: We report a case of prostatic carcinosarcoma, a rare variant of prostatic cancer, which is composed of a mixture of epithelial and mesenchymal components with a generally poor outcome. Aims and methods: We aim to identify molecular alterations, in particular copy number variations of AR and c-MYC genes, methylation and expression of glutathione S-transferase P1 (GSTP1), programmed death-ligand 1 (PD-L1), AR, and phosphorylated AR expression. Results: We found a distinct molecular pattern between adenocarcinoma and carcinosarcoma, which was characterized by high AR copy number variation gain; positive expression of PD-L1, AR, and phosphorylated AR; low espression of GSTP1 in epithelial component. The sarcomatoid component had a lower gain of the AR gene, and no expression of PD-L1, AR, phosphorylated AR, or GSTP1. Both components had a gain of c-MYC copy number variation. Conclusions: Our findings suggest that carcinosarcoma has specific molecular characteristics that could be indicative for early diagnosis and treatment selection.

Original languageEnglish
Pages (from-to)540-544
Number of pages5
JournalInternational Journal of Biological Markers
Volume33
Issue number4
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Androgen receptor
  • Carcinosarcoma
  • Case report
  • Molecular characterization
  • Prostate cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Clinical Biochemistry
  • Cancer Research

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  • Cite this

    Salvi, S., Casadio, V., Martignano, F., Gurioli, G., Tumedei, M. M., Calistri, D., Gunelli, R., & Costantini, M. (2018). Carcinosarcoma of the prostate: Case report with molecular and histological characterization. International Journal of Biological Markers, 33(4), 540-544. https://doi.org/10.1177/1724600818791463