Cardiac alterations in 36 consecutive patients with idiopathic haemochromatosis: Polygraphic and echocardiographic evaluation

G. Cecchetti, A. Binda, A. Piperno, F. Nador, S. Fargion, G. Fiorelli

Research output: Contribution to journalArticlepeer-review

Abstract

Thirty-six consecutive patients with idiopathic haemochromatosis (IH) were studied by electrocardiography (ECG), polygraphy, M-mode and 2-D echocardiography and Doppler-echocardiography. No significant correlations were found between ECG, PEP/LVET ratio and echocardiographic measurements. Left ventricular (LV) enlargement with impaired LV systolic function was present only in three patients (5·5%), of whom two died during iron-depleting therapy because of cardiovascular complications. Compared with controls, echocardiographic abnormalities were significantly more frequent and marked in subjects with higher iron overload than in those in whom it was lower. Ten patients were studied before and after iron depletion, nine of whom had only mild echocardiographic abnormalities at baseline examination. Significant reduction of end-diastolic thickness of the interventricular septum and LV mass (P

Original languageEnglish
Pages (from-to)224-230
Number of pages7
JournalEuropean Heart Journal
Volume12
Issue number2
Publication statusPublished - 1991

Keywords

  • Cardiomyopathy
  • Echocardiography
  • Idiopathic haemochromatosis
  • Iron overload
  • Polycardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology

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