Cardiac and arrhythmic complications in patients with COVID-19

Adriano Nunes Kochi, Ana Paula Tagliari, Giovanni Battista Forleo, Gaetano Michele Fassini, Claudio Tondo

Research output: Contribution to journalReview articlepeer-review


In December 2019, the world started to face a new pandemic situation, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Although coronavirus disease (COVID-19) clinical manifestations are mainly respiratory, major cardiac complications are being reported. Cardiac manifestations etiology seems to be multifactorial, comprising direct viral myocardial damage, hypoxia, hypotension, enhanced inflammatory status, ACE2-receptors downregulation, drug toxicity, endogenous catecholamine adrenergic status, among others. Studies evaluating patients with COVID-19 presenting cardiac injury markers show that it is associated with poorer outcomes, and arrhythmic events are not uncommon. Besides, drugs currently used to treat the COVID-19 are known to prolong the QT interval and can have a proarrhythmic propensity. This review focus on COVID-19 cardiac and arrhythmic manifestations and, in parallel, makes an appraisal of other virus epidemics as SARS-CoV, Middle East respiratory syndrome coronavirus, and H1N1 influenza.

Original languageEnglish
Pages (from-to)1003-1008
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Issue number5
Publication statusPublished - May 1 2020


  • arrhythmia
  • COVID-19
  • myocardial damage
  • myocarditis
  • SARS-CoV-2

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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