Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: Role in functional capacity and mortality

Luciana Jorge, Bruno Rodrigues, Kaleizu Teodoro Rosa, Christiane Malfitano, Tatiana Carolina Alba Loureiro, Alessandra Medeiros, Rui Curi, Patricia Chakur Brum, Silvia Lacchini, Nicola Montano, Kátia De Angelis, Maria Cláudia Irigoyen

Research output: Contribution to journalArticle

Abstract

Aims To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO 2 max), and mortality after myocardial infarction (MI) in rats. Methods and resultsMale Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 5070 VO 2 max). Left ventricular function was evaluated non-invasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 ± 6) compared with SI (34 ± 5) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13) group compared with the SI (54) group. ConclusionEarly aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI.

Original languageEnglish
Pages (from-to)904-912
Number of pages9
JournalEuropean Heart Journal
Volume32
Issue number7
DOIs
Publication statusPublished - Apr 2011

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Exercise
Mortality
Myocardial Infarction
Left Ventricular Function
Regional Blood Flow
Cardiac Output
Baroreflex
Microspheres
Oxygen Consumption
Vascular Endothelial Growth Factor A
Wistar Rats
Heart Rate
Hemodynamics
Messenger RNA

Keywords

  • Autonomic function
  • Blood flow
  • Cardiac function
  • Exercise training
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats : Role in functional capacity and mortality. / Jorge, Luciana; Rodrigues, Bruno; Rosa, Kaleizu Teodoro; Malfitano, Christiane; Loureiro, Tatiana Carolina Alba; Medeiros, Alessandra; Curi, Rui; Brum, Patricia Chakur; Lacchini, Silvia; Montano, Nicola; De Angelis, Kátia; Irigoyen, Maria Cláudia.

In: European Heart Journal, Vol. 32, No. 7, 04.2011, p. 904-912.

Research output: Contribution to journalArticle

Jorge, L, Rodrigues, B, Rosa, KT, Malfitano, C, Loureiro, TCA, Medeiros, A, Curi, R, Brum, PC, Lacchini, S, Montano, N, De Angelis, K & Irigoyen, MC 2011, 'Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats: Role in functional capacity and mortality', European Heart Journal, vol. 32, no. 7, pp. 904-912. https://doi.org/10.1093/eurheartj/ehq244
Jorge, Luciana ; Rodrigues, Bruno ; Rosa, Kaleizu Teodoro ; Malfitano, Christiane ; Loureiro, Tatiana Carolina Alba ; Medeiros, Alessandra ; Curi, Rui ; Brum, Patricia Chakur ; Lacchini, Silvia ; Montano, Nicola ; De Angelis, Kátia ; Irigoyen, Maria Cláudia. / Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats : Role in functional capacity and mortality. In: European Heart Journal. 2011 ; Vol. 32, No. 7. pp. 904-912.
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AU - Malfitano, Christiane

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AU - Curi, Rui

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