Abstract
Aims To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO 2 max), and mortality after myocardial infarction (MI) in rats. Methods and resultsMale Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 5070 VO 2 max). Left ventricular function was evaluated non-invasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 ± 6) compared with SI (34 ± 5) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13) group compared with the SI (54) group. ConclusionEarly aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI.
| Original language | English |
|---|---|
| Pages (from-to) | 904-912 |
| Number of pages | 9 |
| Journal | European Heart Journal |
| Volume | 32 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Apr 2011 |
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Keywords
- Autonomic function
- Blood flow
- Cardiac function
- Exercise training
- Myocardial infarction
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats : Role in functional capacity and mortality. / Jorge, Luciana; Rodrigues, Bruno; Rosa, Kaleizu Teodoro; Malfitano, Christiane; Loureiro, Tatiana Carolina Alba; Medeiros, Alessandra; Curi, Rui; Brum, Patricia Chakur; Lacchini, Silvia; Montano, Nicola; De Angelis, Kátia; Irigoyen, Maria Cláudia.
In: European Heart Journal, Vol. 32, No. 7, 04.2011, p. 904-912.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiac and peripheral adjustments induced by early exercise training intervention were associated with autonomic improvement in infarcted rats
T2 - Role in functional capacity and mortality
AU - Jorge, Luciana
AU - Rodrigues, Bruno
AU - Rosa, Kaleizu Teodoro
AU - Malfitano, Christiane
AU - Loureiro, Tatiana Carolina Alba
AU - Medeiros, Alessandra
AU - Curi, Rui
AU - Brum, Patricia Chakur
AU - Lacchini, Silvia
AU - Montano, Nicola
AU - De Angelis, Kátia
AU - Irigoyen, Maria Cláudia
PY - 2011/4
Y1 - 2011/4
N2 - Aims To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO 2 max), and mortality after myocardial infarction (MI) in rats. Methods and resultsMale Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 5070 VO 2 max). Left ventricular function was evaluated non-invasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 ± 6) compared with SI (34 ± 5) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13) group compared with the SI (54) group. ConclusionEarly aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI.
AB - Aims To test the effects of early exercise training (ET) on left ventricular (LV) and autonomic functions, haemodynamics, tissues blood flows (BFs), maximal oxygen consumption (VO 2 max), and mortality after myocardial infarction (MI) in rats. Methods and resultsMale Wistar rats were divided into: control (C), sedentary-infarcted (SI), and trained-infarcted (TI). One week after MI, TI group underwent an ET protocol (90 days, 5070 VO 2 max). Left ventricular function was evaluated non-invasively and invasively. Baroreflex sensitivity, heart rate variability, and pulse interval were measured. Cardiac output (CO) and regional BFs were determined using coloured microspheres. Infarcted area was reduced in TI (19 ± 6) compared with SI (34 ± 5) after ET. Exercise training improved the LV and autonomic functions, the CO and regional BF changes induced by MI, as well as increased SERCA2 expression and mRNA vascular endothelial growth factor levels. These changes brought about by ET resulted in mortality rate reduction in the TI (13) group compared with the SI (54) group. ConclusionEarly aerobic ET reduced cardiac and peripheral dysfunctions and preserved cardiovascular autonomic control after MI in trained rats. Consequently, these ET-induced changes resulted in improved functional capacity and survival after MI.
KW - Autonomic function
KW - Blood flow
KW - Cardiac function
KW - Exercise training
KW - Myocardial infarction
UR - http://www.scopus.com/inward/record.url?scp=79953696804&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953696804&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/ehq244
DO - 10.1093/eurheartj/ehq244
M3 - Article
C2 - 20675661
AN - SCOPUS:79953696804
VL - 32
SP - 904
EP - 912
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 7
ER -