Cardiac and Peripheral Autonomic Responses to Orthostatic Stress During Transcutaneous Vagus Nerve Stimulation in Healthy Subjects

Eleonora Tobaldini, Edgar Toschi-Dias, Liliane Appratto de Souza, Karina Rabello Casali, Marco Vicenzi, Giulia Sandrone, Chiara Cogliati, Maria Teresa La Rovere, Gian Domenico Pinna, Nicola Montano

Research output: Contribution to journalArticle

Abstract

Previous studies showed that transcutaneous vagus nerve stimulation (tVNS) modulates the autonomic nervous system (ANS) in resting condition. However, the autonomic regulation in response to an orthostatic challenge during tVNS in healthy subjects remains unknown. We tested the hypothesis that tVNS reduces heart rate (HR) and alters the responsivity of ANS to orthostatic stress in healthy subjects. In a randomized and cross-over trial, thirteen healthy subjects underwent two experimental sessions on different days: (1) tVNS and (2) control. Using a tVNS device, an auricular electrode was placed on the left cymba conchae of the external ear; an electric current with a pulse frequency of 25 Hz and amplitude between 1 and 6 mA was applied. For the assessment of ANS, the beat-to-beat HR and systolic arterial pressure (SAP) were analyzed using linear and nonlinear approaches during clinostatic and orthostatic conditions. In clinostatic conditions, tVNS reduced HR (p < 0.01), SAP variability (p < 0.01), and cardiac and peripheral sympathetic modulation (p < 0.01). The responsivity of the peripheral sympathetic modulation to orthostatic stress during tVNS was significantly higher when compared to the control session (p = 0.03). In conclusion, tVNS reduces the HR and affects cardiac and peripheral autonomic control and increases the responses of peripheral autonomic control to orthostatic stress in healthy subjects.

Original languageEnglish
Article numberE496
JournalJournal of Clinical Medicine
Volume8
Issue number4
DOIs
Publication statusPublished - Apr 11 2019

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Vagus Nerve Stimulation
Transcutaneous Electric Nerve Stimulation
Healthy Volunteers
Autonomic Nervous System
Heart Rate
Arterial Pressure
Blood Pressure
External Ear
Cross-Over Studies
Electrodes
Equipment and Supplies

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Cardiac and Peripheral Autonomic Responses to Orthostatic Stress During Transcutaneous Vagus Nerve Stimulation in Healthy Subjects. / Tobaldini, Eleonora; Toschi-Dias, Edgar; Appratto de Souza, Liliane; Rabello Casali, Karina; Vicenzi, Marco; Sandrone, Giulia; Cogliati, Chiara; La Rovere, Maria Teresa; Pinna, Gian Domenico; Montano, Nicola.

In: Journal of Clinical Medicine, Vol. 8, No. 4, E496, 11.04.2019.

Research output: Contribution to journalArticle

Tobaldini, Eleonora ; Toschi-Dias, Edgar ; Appratto de Souza, Liliane ; Rabello Casali, Karina ; Vicenzi, Marco ; Sandrone, Giulia ; Cogliati, Chiara ; La Rovere, Maria Teresa ; Pinna, Gian Domenico ; Montano, Nicola. / Cardiac and Peripheral Autonomic Responses to Orthostatic Stress During Transcutaneous Vagus Nerve Stimulation in Healthy Subjects. In: Journal of Clinical Medicine. 2019 ; Vol. 8, No. 4.
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