Cardiac and pleuropulmonary AL amyloid imaging with technetium-99m labelled aprotinin

Carlo Aprile, Gabriella Marinone, Raffaella Saponaro, Chiara Bonino, Giampaolo Merlini

Research output: Contribution to journalArticle

Abstract

Antiproteases are known to be present in amyloid deposits. We evaluated the possibility of using an anti-serine protease (aprotinin) labelled with technetium-99m (TcA), usually employed as a cortical renal tracer, for the imaging of amyloid deposits. Because of the known high uptake of TcA by the kidneys, we limited our analysis to extra-abdominal amyloid localizations. We report the scintigraphic findings observed in 24 patients with light chain amyloidosis (AL) and one with a hereditary form who were known or suspected to have extra-abdominal involvement. Planar scans obtained 100 min after i.v. TcA administration showed myocardial accumulation in 11 patients, pleuropulmonary accumulation in nine, pericardial accumulation in two and localization in the neck region (thyroid, salivary glands and tongue) in eight. TcA scintigraphy was negative in five patients without clinical or laboratory evidence of extraabdominal involvement, as well as in 12 control group patients with cardiac and renal diseases. These preliminary results indicate TcA to be a low-cost, readily available radiopharmaceutical for imaging of extra-abdominal involvement in AL type amyloidosis.

Original languageEnglish
Pages (from-to)1393-1401
Number of pages9
JournalEuropean Journal Of Nuclear Medicine
Volume22
Issue number12
DOIs
Publication statusPublished - Dec 1995

Fingerprint

Aprotinin
Technetium
Amyloidosis
Amyloid
Amyloid Plaques
Kidney
Radiopharmaceuticals
Serine Proteases
Salivary Glands
Protease Inhibitors
Tongue
Radionuclide Imaging
Heart Diseases
Thyroid Gland
Neck
Light
Costs and Cost Analysis
Control Groups

Keywords

  • Amyloidosis
  • Antiprotease
  • Aprotinin
  • Radionuclide imaging
  • Technetium-99m

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Cardiac and pleuropulmonary AL amyloid imaging with technetium-99m labelled aprotinin. / Aprile, Carlo; Marinone, Gabriella; Saponaro, Raffaella; Bonino, Chiara; Merlini, Giampaolo.

In: European Journal Of Nuclear Medicine, Vol. 22, No. 12, 12.1995, p. 1393-1401.

Research output: Contribution to journalArticle

Aprile, Carlo ; Marinone, Gabriella ; Saponaro, Raffaella ; Bonino, Chiara ; Merlini, Giampaolo. / Cardiac and pleuropulmonary AL amyloid imaging with technetium-99m labelled aprotinin. In: European Journal Of Nuclear Medicine. 1995 ; Vol. 22, No. 12. pp. 1393-1401.
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