TY - JOUR
T1 - Cardiac arrest and resuscitation in the pediatric intensive care unit
T2 - A prospective multicenter multinational study
AU - del Castillo, Jimena
AU - López-Herce, Jesús
AU - Carrillo, Angel
AU - Cañadas, Sonia
AU - Matamoros, Martha
AU - Rodríguez-Núnez, Antonio
AU - Rodríguez-Calvo, Ana
AU - Castillo, Jimena del
AU - Urbano, Javier
AU - Bellón, Jose María
AU - Dominguez, Pedro
AU - Rodriguez, Roger
AU - Callejas, Allison
AU - Carranza, Douglas
AU - Zerón, Hilda
AU - Calvo, Ana Rodriguez
AU - Marcos, Lorenzo
AU - Cecchetti, Cor rado
AU - Silva, Marta
AU - Cesar, Regina Grigolli
AU - PilarOrive, Javier
AU - Nieva, Ana María
AU - Rodríguez-Núñez, Antonio
AU - Parada, Marta
AU - Teresa, María Angeles García
AU - Rodriguez, Jessica Ortiz
AU - Pasquale, Di Prietro
AU - Delgado, Miguel Angel
AU - Ugidos, Pedro Pablo Oyágüez
AU - Jaén, Roxana Flavia
AU - Solana, Juan Garbayo
AU - Domínguez, Raúl Borrego
AU - Monreal, Víctor
AU - Calvo, Custodio
AU - Orayen, Concepción Goñi
AU - Thomas, Iolster
AU - Iramaín, Ricardo
AU - de Carlos, Juan Car los
AU - Galán, Corsino Rey
AU - Quevedo, Olivia Pérez
AU - Campos, Santiago
AU - Pérez, Sivia Sánchez
AU - Matos, Deolinda
AU - Gómez, Isabel Lucía Benítez
AU - Esquivel, Santiago Hermógenes
AU - Chede, Cecilia Andrea
AU - Bustillo, Gabriel Cassaletti
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Objective: The aim of the study was to analyze the mortality and neurological outcome factors of in-pediatric intensive care unit (in-PICU) cardiac arrest (CA) in a multicenter international study. Patients and methods: It was a prospective observational multicenter study in Latin-American countries, Spain, Portugal, and Italy. A total of 250 children aged from 1 month to 18 years who suffered in-PICU CA were studied. Countries and patient-related variables, arrest life, support-related variables, procedures, and clinical and neurological status at hospital discharge according to the Pediatric Cerebral Performance Category (PCPC) scale were registered. The primary endpoint was survival at hospital discharge and neurological outcome at the same time was the secondary endpoint. Univariate and multivariate logistic regression analyses were performed. Results: Return of spontaneous circulation maintained longer than 20. min was achieved in 172 patients (69.1%) and 101 (40.4%) survived to hospital discharge. In the univariate analysis, oncohematologic diseases, inotropic infusion at the time of CA, sepsis and neurologic causes of CA, primary cardiac arrest, need of adrenaline, bicarbonate or volume expansion during resuscitation, and long duration of resuscitation were related with mortality. In the multivariate logistic regression analysis, factors related to mortality were hemato-oncologic illness and previous treatment with vasoactive drugs at the time of CA event, neurological etiology of CA, and cardiopulmonary resuscitation (CPR) duration for more than 10. min. One year after CA, neurological status was assessed in 65 patients; among them, 81.5% had mild disabilities or none. Conclusions: Survival with good neurological outcome of CA in the PICU is improving. The most important prognostic indicator is the duration of resuscitation.
AB - Objective: The aim of the study was to analyze the mortality and neurological outcome factors of in-pediatric intensive care unit (in-PICU) cardiac arrest (CA) in a multicenter international study. Patients and methods: It was a prospective observational multicenter study in Latin-American countries, Spain, Portugal, and Italy. A total of 250 children aged from 1 month to 18 years who suffered in-PICU CA were studied. Countries and patient-related variables, arrest life, support-related variables, procedures, and clinical and neurological status at hospital discharge according to the Pediatric Cerebral Performance Category (PCPC) scale were registered. The primary endpoint was survival at hospital discharge and neurological outcome at the same time was the secondary endpoint. Univariate and multivariate logistic regression analyses were performed. Results: Return of spontaneous circulation maintained longer than 20. min was achieved in 172 patients (69.1%) and 101 (40.4%) survived to hospital discharge. In the univariate analysis, oncohematologic diseases, inotropic infusion at the time of CA, sepsis and neurologic causes of CA, primary cardiac arrest, need of adrenaline, bicarbonate or volume expansion during resuscitation, and long duration of resuscitation were related with mortality. In the multivariate logistic regression analysis, factors related to mortality were hemato-oncologic illness and previous treatment with vasoactive drugs at the time of CA event, neurological etiology of CA, and cardiopulmonary resuscitation (CPR) duration for more than 10. min. One year after CA, neurological status was assessed in 65 patients; among them, 81.5% had mild disabilities or none. Conclusions: Survival with good neurological outcome of CA in the PICU is improving. The most important prognostic indicator is the duration of resuscitation.
KW - Cardiac arrest
KW - Critically ill children
KW - Long-term outcome
KW - Pediatric intensive care unit
KW - Resuscitation
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UR - http://www.scopus.com/inward/citedby.url?scp=84907701570&partnerID=8YFLogxK
U2 - 10.1016/j.resuscitation.2014.06.024
DO - 10.1016/j.resuscitation.2014.06.024
M3 - Article
C2 - 25008138
AN - SCOPUS:84907701570
VL - 85
SP - 1380
EP - 1386
JO - Resuscitation
JF - Resuscitation
SN - 0300-9572
IS - 10
ER -