Despite the wide application of ICDs in clinical practice, their impact on total mortality is still unknown. Several prospective randomized trial are presently under way to compare the effects of ICD therapy with those of competing therapies on clinical outcome in patients at high risk of sudden death. Preliminary data are now available from CASH trial showing that, when compared with oral propaferone, ICD therapy significantly reduces total mortality in survivors of cardiac arrest. In the same study, retrospective analysis of electrophysiologic drug testing question the predictive power of this technique as a guide to select antiarrhythmic drug therapy. Clinical efficacy of ICD therapy relative to drugs such as beta-blockers and amiodarone is presently under investigation.
|Number of pages||7|
|Journal||New Trends in Arrhythmias|
|Publication status||Published - 1993|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine