Cardiac autonomic control and complexity during sleep are preserved after chronic sleep restriction in healthy subjects

Eleonora Tobaldini, Naima Covassin, Andrew Calvin, Prachi Singh, Jan Bukartyk, Shiang Wang, Nicola Montano, Virend K. Somers

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Acute sleep deprivation (SD) alters cardiovascular autonomic control (CAC) and is associated with an increased risk of cardiovascular disorders. However, the effects of partial SD on CAC are unclear. Thus, we aimed to investigate the effects of partial SD on CAC during sleep. We randomized seventeen healthy subjects to a restriction group (RES, n = 8, subjects slept two-thirds of normal sleep time based on individual habitual sleep duration for 8 days and 8 nights) or a Control group (CON, n = 9, subjects were allowed to sleep their usual sleep time). Attended polysomnographic (PSG) studies were performed every night; a subset of them was selected for the analysis at baseline (day 3-D3), the first night after sleep restriction (day 5-D5), at the end of sleep restriction period (day 11-D11), and at the end of recovery phase (day 14-D14). We extracted electrocardiogram (ECG) and respiration from the PSG and divided into wakefulness (W), nonrapid eye movements (REM) sleep (N2 and N3) and REM sleep. CAC was evaluated by means of linear spectral analysis, nonlinear symbolic analysis and complexity indexes. In both RES and CON groups, sympathetic modulation decreased and parasympathetic modulation increased during N2 and N3 compared to W and REM at D3, D5, D11, D14. Complexity analysis revealed a reduction in complexity during REM compared to NREM sleep in both DEP and CON. After 8 days of moderate SD, cardiac autonomic dynamics, characterized by decreased sympathetic, and increased parasympathetic modulation, and higher cardiac complexity during NREM sleep, compared to W and REM, are preserved.

Original languageEnglish
Article numbere13197
JournalPhysiological Reports
Volume5
Issue number7
DOIs
Publication statusPublished - Apr 1 2017

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Healthy Volunteers
Sleep
Sleep Deprivation
REM Sleep
Systems Analysis
Wakefulness
Eye Movements
Electrocardiography
Respiration
Control Groups

Keywords

  • Autonomic nervous system
  • complexity
  • heart rate variability
  • sleep deprivation
  • symbolic analysis
  • sympathetic

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology
  • Medicine(all)

Cite this

Cardiac autonomic control and complexity during sleep are preserved after chronic sleep restriction in healthy subjects. / Tobaldini, Eleonora; Covassin, Naima; Calvin, Andrew; Singh, Prachi; Bukartyk, Jan; Wang, Shiang; Montano, Nicola; Somers, Virend K.

In: Physiological Reports, Vol. 5, No. 7, e13197, 01.04.2017.

Research output: Contribution to journalArticle

Tobaldini, Eleonora ; Covassin, Naima ; Calvin, Andrew ; Singh, Prachi ; Bukartyk, Jan ; Wang, Shiang ; Montano, Nicola ; Somers, Virend K. / Cardiac autonomic control and complexity during sleep are preserved after chronic sleep restriction in healthy subjects. In: Physiological Reports. 2017 ; Vol. 5, No. 7.
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