Cardiac autonomic derangement and arrhythmias in right-sided stroke with insular involvement

Furio Colivicchi, Andrea Bassi, Massimo Santini, Carlo Caltagirone

Research output: Contribution to journalArticlepeer-review


Background and Purpose-The insula of the right cerebral hemisphere may have a major role in cardiac autonomic control. This study was aimed at assessing the effects of acute right insular ischemic damage on heart rate variability (HRV) and arrhythmias. Methods-Holter monitoring for 24 hours was performed in 103 consecutive patients with first-ever acute ischemic stroke. Time and frequency domain measures of HRV and arrhythmias were considered in all cases. Results-Forty-nine patients (47.5%) had a right-sided infarction, whereas 54 (52.5%) had a left-sided infarction. Insular involvement was present in 33 patients with right-sided stroke (67.3%) and in 36 patients with left-sided stroke (66.6%). When compared with all other stroke patients, subjects with right-sided insular damage showed significantly lower values of the standard deviation of all normal-to-normal (SDNN) R wave to R wave (RR) intervals and of the root mean square of differences (rMSSD) of adjacent normal-to-normal RR intervals, and higher low-frequency/high-frequency ratio values (P

Original languageEnglish
Pages (from-to)2094-2098
Number of pages5
Issue number9
Publication statusPublished - Sep 2004


  • Arrhythmia
  • Heart rate
  • Stroke, acute

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)


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