Cardiac autonomic function during sleep of never-depressed borderline subjects: A pilot study

Marco Battaglia; Luigi Ferini-Strambi; Salvatore Smirne; Luana Bernardeschi; Alessandro Oldani; Laura Bellodi

Cardiac autonomic function during sleep of never-depressed borderline subjects: A pilot study

Marco Battaglia, Luigi Ferini-Strambi, Salvatore Smirne, Luana Bernardeschi, Alessandro Oldani, Laura Bellodi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

In a controlled 48 h ambulatory polysomnographic study of never-depressed subjects with DSM-III-R borderline (BDL) personality disorder (PD) we obtained measures of tonic and phasic heart rate variability. Subjects with BDL PD showed a significantly smaller index of tonic heart rate decrease during NREM sleep than normal controls. This is unlikely to be a state-dependent finding and it may derive from relative augmentation of adrenergic function compared to cholinergic function between wakefulness and NREM sleep. Hyperadrenergic states in BDL PD have already been suggested by studies of other biological indicators: a smaller index of tonic heart rate decrease may be a further correlate of core psychobiological dimensions such as impulsivity and affective instability.

Original language	English
Pages (from-to)	397-405
Number of pages	9
Journal	Journal of Psychiatric Research
Volume	29
Issue number	5
Publication status	Published - Sep 1995

ASJC Scopus subject areas

Biological Psychiatry
Psychiatry and Mental health
Psychology(all)

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title = "Cardiac autonomic function during sleep of never-depressed borderline subjects: A pilot study",

abstract = "In a controlled 48 h ambulatory polysomnographic study of never-depressed subjects with DSM-III-R borderline (BDL) personality disorder (PD) we obtained measures of tonic and phasic heart rate variability. Subjects with BDL PD showed a significantly smaller index of tonic heart rate decrease during NREM sleep than normal controls. This is unlikely to be a state-dependent finding and it may derive from relative augmentation of adrenergic function compared to cholinergic function between wakefulness and NREM sleep. Hyperadrenergic states in BDL PD have already been suggested by studies of other biological indicators: a smaller index of tonic heart rate decrease may be a further correlate of core psychobiological dimensions such as impulsivity and affective instability.",

author = "Marco Battaglia and Luigi Ferini-Strambi and Salvatore Smirne and Luana Bernardeschi and Alessandro Oldani and Laura Bellodi",

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AU - Battaglia, Marco

AU - Ferini-Strambi, Luigi

AU - Smirne, Salvatore

AU - Bernardeschi, Luana

AU - Oldani, Alessandro

AU - Bellodi, Laura

PY - 1995/9

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