TY - JOUR
T1 - Cardiac Biomarker Release after CABG with Different Surgical Techniques
AU - Crescenzi, Giuseppe
AU - Cedrati, Valeria
AU - Landoni, Giovanni
AU - Scandroglio, Anna Mara
AU - Bignami, Elena
AU - Bove, Tiziana
AU - Leoni, Albino
AU - Aletti, Giacomo
AU - Zangrillo, Alberto
PY - 2004/2
Y1 - 2004/2
N2 - Objective: To investigate the release of cardiac biomarkers (troponin I and CK-MB) in patients undergoing coronary artery bypass graft (CABG) with or without cardiopulmonary bypass (CPB). Design: Prospective study, Setting: University tertiary hospital. Participants: Sixty-five consecutive patients undergoing coronary artery bypass grafting (≥2 vessel disease, ejection fraction ≥0.35%, elective procedure). Interventions: Cardiac biomarkers were measured before surgery, at intensive care unit arrival, 4 and 18 hours after the end of the procedure. Measurements and Main Results: Cardiac biomarker release was higher in on-pump than in off-pump patients at every time point. On multivariate analysis, CPB (p ≤ 0.0001), number of distal grafts (p = 0.005), and hypertension treatment (p = 0.03) were the only independent predictors of peak cardiac troponin release. Conclusions: Cardiac troponin I release after multivessel CABG is associated with the technique. Different values for the normal range should be considered. OPCABG is minimally invasive for the heart as far as myocardial marker release is concerned.
AB - Objective: To investigate the release of cardiac biomarkers (troponin I and CK-MB) in patients undergoing coronary artery bypass graft (CABG) with or without cardiopulmonary bypass (CPB). Design: Prospective study, Setting: University tertiary hospital. Participants: Sixty-five consecutive patients undergoing coronary artery bypass grafting (≥2 vessel disease, ejection fraction ≥0.35%, elective procedure). Interventions: Cardiac biomarkers were measured before surgery, at intensive care unit arrival, 4 and 18 hours after the end of the procedure. Measurements and Main Results: Cardiac biomarker release was higher in on-pump than in off-pump patients at every time point. On multivariate analysis, CPB (p ≤ 0.0001), number of distal grafts (p = 0.005), and hypertension treatment (p = 0.03) were the only independent predictors of peak cardiac troponin release. Conclusions: Cardiac troponin I release after multivessel CABG is associated with the technique. Different values for the normal range should be considered. OPCABG is minimally invasive for the heart as far as myocardial marker release is concerned.
KW - Cardiac anesthesia
KW - Cardiac biomarker
KW - Cardiac surgery
KW - Cardiac troponin I
KW - Coronary artery bypass grafting
KW - Off-pump coronary artery bypass grafting
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U2 - 10.1053/j.jvca.2003.10.007
DO - 10.1053/j.jvca.2003.10.007
M3 - Article
C2 - 14973796
AN - SCOPUS:1242342671
VL - 18
SP - 34
EP - 37
JO - Journal of Cardiothoracic and Vascular Anesthesia
JF - Journal of Cardiothoracic and Vascular Anesthesia
SN - 1053-0770
IS - 1
ER -