Cardiac Biomarker Release after CABG with Different Surgical Techniques

Giuseppe Crescenzi, Valeria Cedrati, Giovanni Landoni, Anna Mara Scandroglio, Elena Bignami, Tiziana Bove, Albino Leoni, Giacomo Aletti, Alberto Zangrillo

Research output: Contribution to journalArticlepeer-review


Objective: To investigate the release of cardiac biomarkers (troponin I and CK-MB) in patients undergoing coronary artery bypass graft (CABG) with or without cardiopulmonary bypass (CPB). Design: Prospective study, Setting: University tertiary hospital. Participants: Sixty-five consecutive patients undergoing coronary artery bypass grafting (≥2 vessel disease, ejection fraction ≥0.35%, elective procedure). Interventions: Cardiac biomarkers were measured before surgery, at intensive care unit arrival, 4 and 18 hours after the end of the procedure. Measurements and Main Results: Cardiac biomarker release was higher in on-pump than in off-pump patients at every time point. On multivariate analysis, CPB (p ≤ 0.0001), number of distal grafts (p = 0.005), and hypertension treatment (p = 0.03) were the only independent predictors of peak cardiac troponin release. Conclusions: Cardiac troponin I release after multivessel CABG is associated with the technique. Different values for the normal range should be considered. OPCABG is minimally invasive for the heart as far as myocardial marker release is concerned.

Original languageEnglish
Pages (from-to)34-37
Number of pages4
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number1
Publication statusPublished - Feb 2004


  • Cardiac anesthesia
  • Cardiac biomarker
  • Cardiac surgery
  • Cardiac troponin I
  • Coronary artery bypass grafting
  • Off-pump coronary artery bypass grafting

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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