Cardiac damage in pediatric carbon monoxide poisoning

C. Gandini, A. F. Castoldi, S. M. Candura, S. Priori, C. Locatelli, R. Butera, C. Bellet, L. Manzo

Research output: Contribution to journalArticle

Abstract

Background: Cardiovascular disorders including myocardial ischemia and heart failure have been described in both laboratory animals and humans following carbon monoxide poisoning. Carbon monoxide cardiotoxicity may be clinically occult and often remains undiagnosed because of the lack of overt symptoms and specific ischemic changes in the electrocardiogram. Routine myocardial necrosis markers have low diagnostic efficiency, particularly in patients with concomitant skeletal muscle necrosis or multiple organ failure complicating carbon monoxide poisoning. Carbon monoxide-induced cardiotoxicity has been investigated rarely in children. Case Report: This paper describes carbon monoxide poisoning in a 12-year-old child who suffered from occult cardiac damage despite mild symptoms and low carboxyhemoglobin concentrations. Myocardial and mitral valve dysfunctions were observed, suggesting an ischemia-like syndrome. Cardiac damage was completely reversible within 1 month. Conclusion: This case report supports that a prolonged carbon monoxide exposure can cause cardiac damage in children even in the absence of specific symptoms, cerebral failure and high carboxyhemoglobin concentrations.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalJournal of Toxicology - Clinical Toxicology
Volume39
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Acute poisoning
  • Carbon monoxide
  • Cardiotoxicity
  • Child
  • Long QT

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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