ECGs and left ventricular systolic time intervals were studied in 26 patients suffering from major depressive disorder treated with clomipramine. ECGs did not show, with one exception, drug-induced changes. The ratio of pre-ejection period to left ventricular ejection time, both corrected for heart rate (PEPc/LVETc), presented no significant changes, as compared with initial findings, in the group of patients considered as a whole. 27 % of patients, however, showed individual percent changes greater than 8 %, both increases and decreases having been observed. Cardiac findings were in no way related to clomipramine plasma levels.
- Drug-induced blocks and cardiac arrhythmias
- Systolic time intervals (STI)
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Neuropsychology and Physiological Psychology