Cardiac effects of clomipramine treatment: ECG and left ventricular systolic time intervals

C. Farovelli; A. Brat; G. Marchetti; F. Franchi; L. Padeletti; A. Michelucci; A. Pastorino

doi:10.1159/000117948

Cardiac effects of clomipramine treatment: ECG and left ventricular systolic time intervals

C. Farovelli, A. Brat, G. Marchetti, F. Franchi, L. Padeletti, A. Michelucci, A. Pastorino

IRCCS Multimedica

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Abstract

ECGs and left ventricular systolic time intervals were studied in 26 patients suffering from major depressive disorder treated with clomipramine. ECGs did not show, with one exception, drug-induced changes. The ratio of pre-ejection period to left ventricular ejection time, both corrected for heart rate (PEPc/LVETc), presented no significant changes, as compared with initial findings, in the group of patients considered as a whole. 27 % of patients, however, showed individual percent changes greater than 8 %, both increases and decreases having been observed. Cardiac findings were in no way related to clomipramine plasma levels.

Original language	English
Pages (from-to)	113-118
Number of pages	6
Journal	Neuropsychobiology
Volume	9
Issue number	2-3
DOIs	https://doi.org/10.1159/000117948
Publication status	Published - 1983

Keywords

Clomipramine
Drug-induced blocks and cardiac arrhythmias
ECG
Systolic time intervals (STI)

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
Neuropsychology and Physiological Psychology
Neuroscience(all)
Psychology(all)

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abstract = "ECGs and left ventricular systolic time intervals were studied in 26 patients suffering from major depressive disorder treated with clomipramine. ECGs did not show, with one exception, drug-induced changes. The ratio of pre-ejection period to left ventricular ejection time, both corrected for heart rate (PEPc/LVETc), presented no significant changes, as compared with initial findings, in the group of patients considered as a whole. 27 % of patients, however, showed individual percent changes greater than 8 %, both increases and decreases having been observed. Cardiac findings were in no way related to clomipramine plasma levels.",

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AU - Farovelli, C.

AU - Brat, A.

AU - Marchetti, G.

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AU - Padeletti, L.

AU - Michelucci, A.

AU - Pastorino, A.

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