Cardiac effects of clomipramine treatment: ECG and left ventricular systolic time intervals

C. Farovelli, A. Brat, G. Marchetti, F. Franchi, L. Padeletti, A. Michelucci, A. Pastorino

Research output: Contribution to journalArticlepeer-review

Abstract

ECGs and left ventricular systolic time intervals were studied in 26 patients suffering from major depressive disorder treated with clomipramine. ECGs did not show, with one exception, drug-induced changes. The ratio of pre-ejection period to left ventricular ejection time, both corrected for heart rate (PEPc/LVETc), presented no significant changes, as compared with initial findings, in the group of patients considered as a whole. 27 % of patients, however, showed individual percent changes greater than 8 %, both increases and decreases having been observed. Cardiac findings were in no way related to clomipramine plasma levels.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalNeuropsychobiology
Volume9
Issue number2-3
DOIs
Publication statusPublished - 1983

Keywords

  • Clomipramine
  • Drug-induced blocks and cardiac arrhythmias
  • ECG
  • Systolic time intervals (STI)

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychology(all)

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