Abstract
ECGs and left ventricular systolic time intervals were studied in 26 patients suffering from major depressive disorder treated with clomipramine. ECGs did not show, with one exception, drug-induced changes. The ratio of pre-ejection period to left ventricular ejection time, both corrected for heart rate (PEPc/LVETc), presented no significant changes, as compared with initial findings, in the group of patients considered as a whole. 27 % of patients, however, showed individual percent changes greater than 8 %, both increases and decreases having been observed. Cardiac findings were in no way related to clomipramine plasma levels.
Original language | English |
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Pages (from-to) | 113-118 |
Number of pages | 6 |
Journal | Neuropsychobiology |
Volume | 9 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - 1983 |
Keywords
- Clomipramine
- Drug-induced blocks and cardiac arrhythmias
- ECG
- Systolic time intervals (STI)
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Neuropsychology and Physiological Psychology
- Neuroscience(all)
- Psychology(all)