Cardiac effects of clomipramine treatment: ECG and left ventricular systolic time intervals

C. Farovelli, A. Brat, G. Marchetti, F. Franchi, L. Padeletti, A. Michelucci, A. Pastorino

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

ECGs and left ventricular systolic time intervals were studied in 26 patients suffering from major depressive disorder treated with clomipramine. ECGs did not show, with one exception, drug-induced changes. The ratio of pre-ejection period to left ventricular ejection time, both corrected for heart rate (PEPc/LVETc), presented no significant changes, as compared with initial findings, in the group of patients considered as a whole. 27 % of patients, however, showed individual percent changes greater than 8 %, both increases and decreases having been observed. Cardiac findings were in no way related to clomipramine plasma levels.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalNeuropsychobiology
Volume9
Issue number2-3
DOIs
Publication statusPublished - 1983

Fingerprint

Clomipramine
Systole
Electrocardiography
Major Depressive Disorder
Therapeutics
Heart Rate
Pharmaceutical Preparations

Keywords

  • Clomipramine
  • Drug-induced blocks and cardiac arrhythmias
  • ECG
  • Systolic time intervals (STI)

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychology(all)

Cite this

Farovelli, C., Brat, A., Marchetti, G., Franchi, F., Padeletti, L., Michelucci, A., & Pastorino, A. (1983). Cardiac effects of clomipramine treatment: ECG and left ventricular systolic time intervals. Neuropsychobiology, 9(2-3), 113-118. https://doi.org/10.1159/000117948

Cardiac effects of clomipramine treatment : ECG and left ventricular systolic time intervals. / Farovelli, C.; Brat, A.; Marchetti, G.; Franchi, F.; Padeletti, L.; Michelucci, A.; Pastorino, A.

In: Neuropsychobiology, Vol. 9, No. 2-3, 1983, p. 113-118.

Research output: Contribution to journalArticle

Farovelli, C, Brat, A, Marchetti, G, Franchi, F, Padeletti, L, Michelucci, A & Pastorino, A 1983, 'Cardiac effects of clomipramine treatment: ECG and left ventricular systolic time intervals', Neuropsychobiology, vol. 9, no. 2-3, pp. 113-118. https://doi.org/10.1159/000117948
Farovelli C, Brat A, Marchetti G, Franchi F, Padeletti L, Michelucci A et al. Cardiac effects of clomipramine treatment: ECG and left ventricular systolic time intervals. Neuropsychobiology. 1983;9(2-3):113-118. https://doi.org/10.1159/000117948
Farovelli, C. ; Brat, A. ; Marchetti, G. ; Franchi, F. ; Padeletti, L. ; Michelucci, A. ; Pastorino, A. / Cardiac effects of clomipramine treatment : ECG and left ventricular systolic time intervals. In: Neuropsychobiology. 1983 ; Vol. 9, No. 2-3. pp. 113-118.
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