Valvole cardiache ingegnerizzate: Stato dell'arte

Translated title of the contribution: Cardiac engineered valves: State of the art

Luca Dainese, Fabio Barili, Daniele Andreini, Anna Guarino, Barbara Micheli, Cristina Anna Borsetti, Gian Luca Polvani, Alessandro Parolari, Melissa Fusari, Paolo Biglioli

Research output: Contribution to journalArticlepeer-review


Engineered heart valves promise to be the ideal heart valve replacement: they have the potential to grow and repair within the host, to minimize inflammatory and immunological responses and to limit thromboembolism. In particular, pediatric patients with congenital defects would greatly benefit from growing replacement materials by reducing the need for surgical reinterventions due to the lack of prosthetic material growth. In fact, viable cells included in engineered heart valves can theoretically adapt to a growing and changing environment exactly as a native biological structure. Engineered heart valves represent thus a novel experimental approach to create autologous, living replacements with the potential to grow, regenerate, and remodel. The aim of this paper is to present a review concerning the research efforts to create a viable engineered heart valve.

Translated title of the contributionCardiac engineered valves: State of the art
Original languageItalian
Pages (from-to)167-172
Number of pages6
JournalGiornale Italiano di Cardiologia
Issue number3
Publication statusPublished - Mar 2008

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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