Cardiac fluoroscopy for the diagnosis of coronary artery disease: A meta analytic review

Renato Gianrossi, Robert Detrano, Antonio Colombo, Victor Froelicher

Research output: Contribution to journalArticlepeer-review


To evaluate variability in the reported accuracy of fluoroscopically detected coronary calcific deposits for predicting angiographic coronary disease, we applied meta analysis to 13 consecutively published reports comparing the results of cardiac fluoroscopy with coronary angiography. Population characteristics and technical and methodologic factors were analyzed. Sensitivity and specificity for predicting serious coronary disease compre quite well with those from the literature on the exercise ECG and the exercise thallium scintigram. Sensitivity increases and specificity decreases more significantly with patient age, and sensitivity is paradoxically lower in laboratories testing patients with more severe disease, as well as when 70% rather than 50% diameter narrowing is used to define angiographic disease. Workup and test review bias were also significantly related to reported accuracy.

Original languageEnglish
Pages (from-to)1179-1188
Number of pages10
JournalAmerican Heart Journal
Issue number5
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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