Abstract
Rheumatoid arthritis (RA) is a systemic disease of unknown etiology characterized by a chronic inflammatory process mainly leading to destruction of synovial membrane of small and major diarthrodial joints. The prevalence of RA within the general adult population is about 1% and female subjects in fertile age result mostly involved. It's an invalidating disease, associated with changes in life quality and a reduced life expectancy. Moreover, we can observe an increased mortality rate in this population early after the onset of the disease. The mortality excess can be partially due to infective, gastrointestinal, renal or pulmonary complications and malignancy (mainly lung cancer and non-Hodgkin lymphoma). Among extra-articular complications, cardiovascular (CV) involvement represents one of the leading causes of morbidity and mortality. Every cardiac structure can be affected by different pathogenic pathways: heart valves, conduction system, myocardium, endocardium, pericardium and coronary arteries. Consequently, different clinical manifestations can be detected, including: pericarditis, myocarditis, myocardial fibrosis, arrhythmias, alterations of conduction system, coronaropathies and ischemic cardiopathy, valvular disease, pulmonary hypertension and heart failure. Considering that early cardiac involvement negatively affects the prognosis, it is mandatory to identify high CV risk RA patients to better define long-term management of this population.
| Original language | Italian |
|---|---|
| Pages (from-to) | 244-253 |
| Number of pages | 10 |
| Journal | Reumatismo |
| Volume | 61 |
| Issue number | 4 |
| Publication status | Published - 2009 |
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ASJC Scopus subject areas
- Rheumatology
Cite this
Il coinvolgimento cardiaco nell'artrite reumatoide. / Turiel, Maurizio; Sitia, S.; Tomasoni, L.; Cicala, S.; Atzeni, F.; Gianturco, L.; Longhi, M.; De Gennaro Colonna, V.; Sarzi-Puttini, P.
In: Reumatismo, Vol. 61, No. 4, 2009, p. 244-253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Il coinvolgimento cardiaco nell'artrite reumatoide
AU - Turiel, Maurizio
AU - Sitia, S.
AU - Tomasoni, L.
AU - Cicala, S.
AU - Atzeni, F.
AU - Gianturco, L.
AU - Longhi, M.
AU - De Gennaro Colonna, V.
AU - Sarzi-Puttini, P.
PY - 2009
Y1 - 2009
N2 - Rheumatoid arthritis (RA) is a systemic disease of unknown etiology characterized by a chronic inflammatory process mainly leading to destruction of synovial membrane of small and major diarthrodial joints. The prevalence of RA within the general adult population is about 1% and female subjects in fertile age result mostly involved. It's an invalidating disease, associated with changes in life quality and a reduced life expectancy. Moreover, we can observe an increased mortality rate in this population early after the onset of the disease. The mortality excess can be partially due to infective, gastrointestinal, renal or pulmonary complications and malignancy (mainly lung cancer and non-Hodgkin lymphoma). Among extra-articular complications, cardiovascular (CV) involvement represents one of the leading causes of morbidity and mortality. Every cardiac structure can be affected by different pathogenic pathways: heart valves, conduction system, myocardium, endocardium, pericardium and coronary arteries. Consequently, different clinical manifestations can be detected, including: pericarditis, myocarditis, myocardial fibrosis, arrhythmias, alterations of conduction system, coronaropathies and ischemic cardiopathy, valvular disease, pulmonary hypertension and heart failure. Considering that early cardiac involvement negatively affects the prognosis, it is mandatory to identify high CV risk RA patients to better define long-term management of this population.
AB - Rheumatoid arthritis (RA) is a systemic disease of unknown etiology characterized by a chronic inflammatory process mainly leading to destruction of synovial membrane of small and major diarthrodial joints. The prevalence of RA within the general adult population is about 1% and female subjects in fertile age result mostly involved. It's an invalidating disease, associated with changes in life quality and a reduced life expectancy. Moreover, we can observe an increased mortality rate in this population early after the onset of the disease. The mortality excess can be partially due to infective, gastrointestinal, renal or pulmonary complications and malignancy (mainly lung cancer and non-Hodgkin lymphoma). Among extra-articular complications, cardiovascular (CV) involvement represents one of the leading causes of morbidity and mortality. Every cardiac structure can be affected by different pathogenic pathways: heart valves, conduction system, myocardium, endocardium, pericardium and coronary arteries. Consequently, different clinical manifestations can be detected, including: pericarditis, myocarditis, myocardial fibrosis, arrhythmias, alterations of conduction system, coronaropathies and ischemic cardiopathy, valvular disease, pulmonary hypertension and heart failure. Considering that early cardiac involvement negatively affects the prognosis, it is mandatory to identify high CV risk RA patients to better define long-term management of this population.
KW - Asymmetric dimethylarginine (ADMA)
KW - Atherosclerosis
KW - Carotid intima-media thickness (IMT)
KW - Coronary flow reserve (CFR)
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=75749140568&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75749140568&partnerID=8YFLogxK
M3 - Articolo
VL - 61
SP - 244
EP - 253
JO - Reumatismo
JF - Reumatismo
SN - 0048-7449
IS - 4
ER -