Cardiac iron removal and functional cardiac improvement by different iron chelation regimens in thalassemia major patients

Elena Cassinerio, Alberto Roghi, Patrizia Pedrotti, Francesca Brevi, Laura Zanaboni, Giovanna Graziadei, Paolo Pattoneri, Angela Milazzo, Maria Domenica Cappellini

Research output: Contribution to journalArticlepeer-review

Abstract

Heart failure due to myocardial iron overload remains the leading cause of morbidity and mortality in adult thalassemia major (TM) patients.We evaluated the removal of cardiac iron and the changes of cardiac function by different iron chelation in TM patients by T2* cardiac magnetic resonance (CMR). Sixty-seven TM patients (27 males/40 females; mean age, 35±6 years) on different chelation regimens underwent T2* CMR at baseline (t0), after 6-14 months (t1) and after 32±7 months (t2). Patients were divided in four groups according to chelation treatment: group A (deferasirox), group B (deferoxamine), group C (combined treatment, deferoxamine plus deferiprone) and group D (deferiprone alone). Myocardial T2* at t0 was

Original languageEnglish
Pages (from-to)1443-1449
Number of pages7
JournalAnnals of Hematology
Volume91
Issue number9
DOIs
Publication statusPublished - Sep 2012

Keywords

  • Cardiac function
  • Cardiac magnetic resonance T2*
  • Chelation therapy
  • Myocardial siderosis
  • Thalassemia major

ASJC Scopus subject areas

  • Hematology

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