Cardiac load and function in hypertension. Ultrasonic and hemodynamic study

Maurizio Guazzi, Cesare Fiorentini, Maria T. Olivari, Alvise Polese

Research output: Contribution to journalArticlepeer-review

Abstract

On the basis of echocardiographic measurements, 46 patients with established, uncomplicated primary hypertension (diastolic pressure = 100 mm Hg) were classified as: those with a normal-sized heart (Group I, 13 patients); those with left ventricular concentric hypertrophy (Group II, 19 patients); and those with left ventricular hypertrophy and enlargement (Group III, 14 patients). Eighteen age-matched healthy subjects were investigated as the controls. The function of both the left and right ventricle, evaluated by the stroke index-filling pressure relation and by the mean rate of ejection, was maintained in Group I, augmented in Group II and reduced in Group III, in comparison with the controls. Left ventricular mean rate of circumferential fiber shortening (Vcf) was normal in Group I, significantly augmented in Group II and definitely reduced in Group III. It could not be established whether the divergent variation from normal of the Vcf in Groups II and III reflected opposite changes in ventricular contractility or in afterload (wall stress during ejection), or both. However, the parallel functional pattern of the right and left ventricle in these two groups suggests a functional interdependence of the two sides which cannot be interpreted in terms of afterload but is best explained by changes in the contractile state of the whole heart.

Original languageEnglish
Pages (from-to)1007-1012
Number of pages6
JournalThe American Journal of Cardiology
Volume44
Issue number5
DOIs
Publication statusPublished - Oct 22 1979

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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