Cardiac magnetic resonance in heart failure with preserved ejection fraction: myocyte, interstitium, microvascular, and metabolic abnormalities

Giovanni Quarta, Mauro Gori, Annamaria Iorio, Emilia D'Elia, James C. Moon, Attilio Iacovoni, Simone Burocchi, Erik B. Schelbert, Paolo Brambilla, Sandro Sironi, Sergio Caravita, Gianfranco Parati, Antonello Gavazzi, Alan S. Maisel, Javed Butler, Carolyn S.P. Lam, Michele Senni

Research output: Contribution to journalReview articlepeer-review

Abstract

Heart failure (HF) with preserved ejection fraction (HFpEF) is a chronic cardiac condition whose prevalence continues to rise, with high social and economic burden, but with no specific approved treatment. Patients diagnosed with HFpEF have a high prevalence of comorbidities and exhibit a high misdiagnosis rate. True HFpEF is likely to have multiple pathophysiological causes – with these causes being clinically ill-defined due to limitations of current measurement techniques. Myocyte, interstitium, microvascular, and metabolic abnormalities have been regarded as key components of the pathophysiology and potential therapeutic targets. Cardiac magnetic resonance (CMR) has the capability to look deeper with a number of tissue characterization techniques which are closer to the underlying specific abnormalities and which could be linked to personalized medicine for HFpEF. This review aims to discuss the potential role of CMR to better define HFpEF phenotypes and to infer measurable therapeutic targets.

Original languageEnglish
Pages (from-to)1065-1075
Number of pages11
JournalEuropean Journal of Heart Failure
Volume22
Issue number7
DOIs
Publication statusPublished - Jul 1 2020

Keywords

  • Cardiac magnetic resonance
  • Heart failure with preserved ejection fraction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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