Cardiac neural regulation involvement in patients with amyotrophic lateral sclerosis

Laura Dalla Vecchia, Anna Lucini, Domenico Volza, Riccardo Sideri, Kalliopi Marinou, Gabriele Mora

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by motor and extramotor neuron loss. Aim of this study was to attempt a better characterization of the cardiac neural regulation in ALS using the heart rate variability analysis. Cardiac neural regulation was altered in all patients, i.e. they showed a low RR variance and an abnormal response to orthostasis. Interestingly, at rest patients could be divided in those with lower and those with higher sympathetic activity than normal. In both cases the response to orthostasis was blunted. These findings suggest that an impairment of the autonomic nervous system is present in ALS with different patterns of cardiac regulation imbalance among patients. It has to be established if such differences depend upon time course of the disease, different clinical entities, or other anatomic, pathological and clinical variables.

Original languageEnglish
Title of host publication2014 8th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2014
PublisherIEEE Computer Society
Pages101-102
Number of pages2
ISBN (Print)9781479939695
DOIs
Publication statusPublished - 2014
Event2014 8th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2014 - Trento, Italy
Duration: May 25 2014May 28 2014

Other

Other2014 8th Conference of the European Study Group on Cardiovascular Oscillations, ESGCO 2014
Country/TerritoryItaly
CityTrento
Period5/25/145/28/14

ASJC Scopus subject areas

  • Biomedical Engineering

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