Cardiac Protection With Volatile Anesthetics in Stenting Procedures

Giovanni Landoni, Alberto Zangrillo, Oliviero Fochi, Giulia Maj, Anna Mara Scandroglio, Andrea Morelli, Luigi Tritapepe, Matteo Montorfano, Antonio Colombo

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Myocardial ischemic damage is reduced by volatile anesthetics in patients undergoing coronary artery bypass graft surgery. The authors tested the hypothesis that low-dose sevoflurane could decrease perioperative myocardial damage, as measured by cTnI release, when compared with placebo, in patients undergoing interventional cardiology procedures. Design: A single-blind, randomized controlled trial. Setting: A university hospital. Participants: Thirty patients undergoing stenting procedures (May 2005) were included in the present study. Interventions: The authors randomly assigned 16 patients to breathe sevoflurane (expired end-tidal concentration 1%) and 14 patients to breathe a placebo oxygen/air mix before stenting procedures. Measurements and Main Results: Postprocedural cardiac troponin I release was measured as a marker of myocardial necrosis. Sixteen patients had detectable cardiac troponin I levels after stenting procedures, with no difference between groups: 10 in the sevoflurane group (16 patients) versus 6 in the placebo group (14 patients) (p = 0.3). No difference in the amount of postprocedural median (interquartile range) cardiac troponin I release was noted between the sevoflurane group, 0.15 (0-4.73) ng/mL, and the placebo group, 0.14 (0-0.87) ng/mL (p = 0.4). Conclusions: Myocardial damage measured by cardiac troponin release was not reduced by the volatile anesthetic sevoflurane during interventional cardiology procedures in this study.

Original languageEnglish
Pages (from-to)543-547
Number of pages5
JournalJournal of Cardiothoracic and Vascular Anesthesia
Volume22
Issue number4
DOIs
Publication statusPublished - Aug 2008

Keywords

  • coronary stenting
  • inhalation anesthetics
  • myocardial ischemia
  • myocardial preconditioning

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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