Cardiac Remodeling, Circulating Biomarkers and Clinical Events in Patients with a History of Atrial Fibrillation. Data from the GISSI-AF Trial

Lidia Staszewsky, Serge Masson, Simona Barlera, Marcello Disertori, Silvana Boni, Daniele Bertoli, Olga Vriz, Elena Pasotti, Prisca Zeni, Tarcisio Vago, Aldo P. Maggioni, Gianni Tognoni, Roberto Latini

Research output: Contribution to journalArticle

Abstract

Purpose: Atrial fibrillation (AF) is the most common arrhythmia and has an increasing impact on public health because of its morbidity and mortality. Clinical and diagnostic tests to predict the recurrence of arrhythmia and clinical events before AF becomes permanent are still an open issue. Methods: 307 out of 1442 patients in sinus rhythm, at high risk of recurrence of AF enrolled in the GISSI-AF study, participated in a substudy with echocardiographic and biohumoral evaluation at baseline and at 12-month follow-up. The relations between biomarker concentrations and echocardiographic parameters with study endpoints in 1 year, were analysed by a stepwise multivariable Cox model (entry criteria p <0.5 and stay criteria p <0.2). Results: The echocardiographic variables, cardiac markers and clinical variables considered in the statistical model indicated a higher concentration of NT-proBNP at baseline as the strongest factor related to time of first AF recurrence (HR 1.42; 95 %CI 1.23–1.46), first CV hospitalization (HR 1.58; 95 %CI 1.31–1.92) and increasing duration of recurrent AF (OR 2.16; 95 %CI 1.52–3.08). Valsartan treatment was not related to clinical events. Conclusions: In patients in sinus rhythm with a history of AF a higher concentration of NT-proBNP at baseline was the strongest independent risk factor for first AF recurrence and its duration, and for the first hospital admission for cardiovascular reasons.

Original languageEnglish
Pages (from-to)551-561
Number of pages11
JournalCardiovascular Drugs and Therapy
Volume29
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Atrial fibrillation
  • Atrial fibrillation recurrence
  • Circulating biomarkers
  • Clinical trial
  • Echocardiography
  • Hospitalizations
  • Natriuretic peptides

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine
  • Pharmacology

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  • Cite this

    Staszewsky, L., Masson, S., Barlera, S., Disertori, M., Boni, S., Bertoli, D., Vriz, O., Pasotti, E., Zeni, P., Vago, T., Maggioni, A. P., Tognoni, G., & Latini, R. (2015). Cardiac Remodeling, Circulating Biomarkers and Clinical Events in Patients with a History of Atrial Fibrillation. Data from the GISSI-AF Trial. Cardiovascular Drugs and Therapy, 29(6), 551-561. https://doi.org/10.1007/s10557-015-6624-3