Cardiac resynchronization therapy: Gender related differences in left ventricular reverse remodeling

Alessio Lilli, Giuseppe Ricciardi, Maria Cristina Porciani, Alessandro Paoletti Perini, Paolo Pieragnoli, Nicola Musilli, Andrea Colella, Stefano Del Pace, Antonio Michelucci, Federico Turreni, Massimo Sassara, Augusto Achilli, S. Serge Barold, Luigi Padeletti

Research output: Contribution to journalArticlepeer-review


Aim: Gender related differences in epidemiology, treatment, and prognosis of heart failure (HF) have been reported. We examined the sex influence in patients treated with cardiac resynchronization therapy (CRT). Methods and Results: Out of 334 consecutive HF patients (19.7% women) who underwent CRT, 195 patients reached clinical and echocardiographic evaluation at six and 12 months and were selected for analysis. A reduction in left ventricular (LV) end-diastolic volume/m2 (EDVi) and end systolic volume/m2 (ESVi) was evident in the overall population at six months (P <0.001) and from six to 12 months (P <0.001). Compared to men, women showed significantly greater changes in LV volumes at mid (P <0.05) and long-term (P <0.001) follow-up and a significantly higher LV ejection fraction (EF) (40.8 ± 12.3 vs 34.1 ± 10.1, P <0.01) at one year. Multiple regression analysis, including several demographic and clinical parameters, revealed that female gender is independently associated with greater reduction in LV ESVi. At the 12-month follow-up, the proportion of responders (defined in terms of ESV reduction by at least 10%) was higher in women than in men (76.1% vs 59.3%, P <0.05). Conclusions: CRT induced a gender specific LV remodeling response.

Original languageEnglish
Pages (from-to)1349-1355
Number of pages7
JournalPACE - Pacing and Clinical Electrophysiology
Issue number11
Publication statusPublished - Nov 2007


  • Cardiac resynchronisation
  • Heart failure
  • Reverse remodeling
  • Women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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