TY - JOUR
T1 - Cardiac resynchronization therapy
T2 - Gender related differences in left ventricular reverse remodeling
AU - Lilli, Alessio
AU - Ricciardi, Giuseppe
AU - Porciani, Maria Cristina
AU - Perini, Alessandro Paoletti
AU - Pieragnoli, Paolo
AU - Musilli, Nicola
AU - Colella, Andrea
AU - Pace, Stefano Del
AU - Michelucci, Antonio
AU - Turreni, Federico
AU - Sassara, Massimo
AU - Achilli, Augusto
AU - Serge Barold, S.
AU - Padeletti, Luigi
PY - 2007/11
Y1 - 2007/11
N2 - Aim: Gender related differences in epidemiology, treatment, and prognosis of heart failure (HF) have been reported. We examined the sex influence in patients treated with cardiac resynchronization therapy (CRT). Methods and Results: Out of 334 consecutive HF patients (19.7% women) who underwent CRT, 195 patients reached clinical and echocardiographic evaluation at six and 12 months and were selected for analysis. A reduction in left ventricular (LV) end-diastolic volume/m2 (EDVi) and end systolic volume/m2 (ESVi) was evident in the overall population at six months (P <0.001) and from six to 12 months (P <0.001). Compared to men, women showed significantly greater changes in LV volumes at mid (P <0.05) and long-term (P <0.001) follow-up and a significantly higher LV ejection fraction (EF) (40.8 ± 12.3 vs 34.1 ± 10.1, P <0.01) at one year. Multiple regression analysis, including several demographic and clinical parameters, revealed that female gender is independently associated with greater reduction in LV ESVi. At the 12-month follow-up, the proportion of responders (defined in terms of ESV reduction by at least 10%) was higher in women than in men (76.1% vs 59.3%, P <0.05). Conclusions: CRT induced a gender specific LV remodeling response.
AB - Aim: Gender related differences in epidemiology, treatment, and prognosis of heart failure (HF) have been reported. We examined the sex influence in patients treated with cardiac resynchronization therapy (CRT). Methods and Results: Out of 334 consecutive HF patients (19.7% women) who underwent CRT, 195 patients reached clinical and echocardiographic evaluation at six and 12 months and were selected for analysis. A reduction in left ventricular (LV) end-diastolic volume/m2 (EDVi) and end systolic volume/m2 (ESVi) was evident in the overall population at six months (P <0.001) and from six to 12 months (P <0.001). Compared to men, women showed significantly greater changes in LV volumes at mid (P <0.05) and long-term (P <0.001) follow-up and a significantly higher LV ejection fraction (EF) (40.8 ± 12.3 vs 34.1 ± 10.1, P <0.01) at one year. Multiple regression analysis, including several demographic and clinical parameters, revealed that female gender is independently associated with greater reduction in LV ESVi. At the 12-month follow-up, the proportion of responders (defined in terms of ESV reduction by at least 10%) was higher in women than in men (76.1% vs 59.3%, P <0.05). Conclusions: CRT induced a gender specific LV remodeling response.
KW - Cardiac resynchronisation
KW - Heart failure
KW - Reverse remodeling
KW - Women
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U2 - 10.1111/j.1540-8159.2007.00870.x
DO - 10.1111/j.1540-8159.2007.00870.x
M3 - Article
C2 - 17976098
AN - SCOPUS:35748961671
VL - 30
SP - 1349
EP - 1355
JO - PACE - Pacing and Clinical Electrophysiology
JF - PACE - Pacing and Clinical Electrophysiology
SN - 0147-8389
IS - 11
ER -