Cardiac resynchronization therapy in heart failure patients with less severe left ventricular dysfunction

Ofek Y. Hai, Robert J. Mentz, Faiez Zannad, Maurizio Gasparini, Gaetano M. De Ferrari, Jean Claude Daubert, Johannes Holzmeister, Carolyn S P Lam, Thierry Pochet, Alphons Vincent, Cecilia Linde

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiac resynchronization therapy is beneficial in heart failure patients with LVEF ≤35% and electrical dyssynchrony. However, its effects among patients with less severe LV dysfunction have not been established. Recent post-hoc analyses of landmark CRT trials suggest that CRT benefit may be present in patients with LVEF >35% and is associated with improvement in cardiac reverse remodelling, all-cause mortality, and need for heart failure hospitalizations. This review summarizes the currently available literature regarding the potential impact of CRT in patients with more modest reductions in LVEF.

Original languageEnglish
Pages (from-to)135-143
Number of pages9
JournalEuropean Journal of Heart Failure
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • Cardiac resynchronization therapy
  • Heart failure
  • Left ventricular ejection fraction
  • Reverse cardiac remodelling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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