TY - JOUR
T1 - Cardiac resynchronization therapy in heart failure patients with less severe left ventricular dysfunction
AU - Hai, Ofek Y.
AU - Mentz, Robert J.
AU - Zannad, Faiez
AU - Gasparini, Maurizio
AU - De Ferrari, Gaetano M.
AU - Daubert, Jean Claude
AU - Holzmeister, Johannes
AU - Lam, Carolyn S P
AU - Pochet, Thierry
AU - Vincent, Alphons
AU - Linde, Cecilia
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Cardiac resynchronization therapy is beneficial in heart failure patients with LVEF ≤35% and electrical dyssynchrony. However, its effects among patients with less severe LV dysfunction have not been established. Recent post-hoc analyses of landmark CRT trials suggest that CRT benefit may be present in patients with LVEF >35% and is associated with improvement in cardiac reverse remodelling, all-cause mortality, and need for heart failure hospitalizations. This review summarizes the currently available literature regarding the potential impact of CRT in patients with more modest reductions in LVEF.
AB - Cardiac resynchronization therapy is beneficial in heart failure patients with LVEF ≤35% and electrical dyssynchrony. However, its effects among patients with less severe LV dysfunction have not been established. Recent post-hoc analyses of landmark CRT trials suggest that CRT benefit may be present in patients with LVEF >35% and is associated with improvement in cardiac reverse remodelling, all-cause mortality, and need for heart failure hospitalizations. This review summarizes the currently available literature regarding the potential impact of CRT in patients with more modest reductions in LVEF.
KW - Cardiac resynchronization therapy
KW - Heart failure
KW - Left ventricular ejection fraction
KW - Reverse cardiac remodelling
UR - http://www.scopus.com/inward/record.url?scp=84923048453&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84923048453&partnerID=8YFLogxK
U2 - 10.1002/ejhf.208
DO - 10.1002/ejhf.208
M3 - Article
C2 - 25469668
AN - SCOPUS:84923048453
VL - 17
SP - 135
EP - 143
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
SN - 1388-9842
IS - 2
ER -