Cardiac resynchronization therapy in heart failure patients with less severe left ventricular dysfunction

Ofek Y. Hai; Robert J. Mentz; Faiez Zannad; Maurizio Gasparini; Gaetano M. De Ferrari; Jean Claude Daubert; Johannes Holzmeister; Carolyn S P Lam; Thierry Pochet; Alphons Vincent; Cecilia Linde

doi:10.1002/ejhf.208

Cardiac resynchronization therapy in heart failure patients with less severe left ventricular dysfunction

Ofek Y. Hai, Robert J. Mentz, Faiez Zannad, Maurizio Gasparini, Gaetano M. De Ferrari, Jean Claude Daubert, Johannes Holzmeister, Carolyn S P Lam, Thierry Pochet, Alphons Vincent, Cecilia Linde

Research output: Contribution to journal › Article › peer-review

Abstract

Cardiac resynchronization therapy is beneficial in heart failure patients with LVEF ≤35% and electrical dyssynchrony. However, its effects among patients with less severe LV dysfunction have not been established. Recent post-hoc analyses of landmark CRT trials suggest that CRT benefit may be present in patients with LVEF >35% and is associated with improvement in cardiac reverse remodelling, all-cause mortality, and need for heart failure hospitalizations. This review summarizes the currently available literature regarding the potential impact of CRT in patients with more modest reductions in LVEF.

Original language	English
Pages (from-to)	135-143
Number of pages	9
Journal	European Journal of Heart Failure
Volume	17
Issue number	2
DOIs	https://doi.org/10.1002/ejhf.208
Publication status	Published - Feb 1 2015

Keywords

Cardiac resynchronization therapy
Heart failure
Left ventricular ejection fraction
Reverse cardiac remodelling

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Medicine(all)

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10.1002/ejhf.208

Cite this

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abstract = "Cardiac resynchronization therapy is beneficial in heart failure patients with LVEF ≤35% and electrical dyssynchrony. However, its effects among patients with less severe LV dysfunction have not been established. Recent post-hoc analyses of landmark CRT trials suggest that CRT benefit may be present in patients with LVEF >35% and is associated with improvement in cardiac reverse remodelling, all-cause mortality, and need for heart failure hospitalizations. This review summarizes the currently available literature regarding the potential impact of CRT in patients with more modest reductions in LVEF.",

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AU - Hai, Ofek Y.

AU - Mentz, Robert J.

AU - Zannad, Faiez

AU - Gasparini, Maurizio

AU - De Ferrari, Gaetano M.

AU - Daubert, Jean Claude

AU - Holzmeister, Johannes

AU - Lam, Carolyn S P

AU - Pochet, Thierry

AU - Vincent, Alphons

AU - Linde, Cecilia

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AB - Cardiac resynchronization therapy is beneficial in heart failure patients with LVEF ≤35% and electrical dyssynchrony. However, its effects among patients with less severe LV dysfunction have not been established. Recent post-hoc analyses of landmark CRT trials suggest that CRT benefit may be present in patients with LVEF >35% and is associated with improvement in cardiac reverse remodelling, all-cause mortality, and need for heart failure hospitalizations. This review summarizes the currently available literature regarding the potential impact of CRT in patients with more modest reductions in LVEF.

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KW - Heart failure

KW - Left ventricular ejection fraction

KW - Reverse cardiac remodelling

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Cardiac resynchronization therapy in heart failure patients with less severe left ventricular dysfunction

Abstract

Keywords

ASJC Scopus subject areas

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