Cardiac resynchronization therapy is more effective in women than in men: The MADIT-CRT (multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy) trial

Aysha Arshad, Arthur J. Moss, Elyse Foster, Luigi Padeletti, Alon Barsheshet, Ilan Goldenberg, Henry Greenberg, W. Jackson Hall, Scott McNitt, Wojciech Zareba, Scott Solomon, Jonathan S. Steinberg

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The purpose of this study was to investigate the factors related to sex-specific outcomes for death and heart failure events in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) trial. Background: In the MADIT-CRT trial, women seemed to achieve a better result from resynchronization therapy than men. Methods: All 1,820 patients (453 female and 1,367 male) enrolled in the MADIT-CRT trial were included in this sex-specific outcome analysis that compared the effect of cardiac resynchronization therapy with defibrillator (CRT-D) relative to implanted cardioverter-defibrillator (ICD) on death or heart failure (whichever came first), heart failure only, and death at any time. Results: Female patients were more likely to have nonischemic cardiomyopathy and left bundle branch block and less likely to have renal dysfunction than male patients. Overall, female patients had a better result from CRT-D therapy than male patients, with a significant 69% reduction in death or heart failure (hazard ratio: 0.31, p <0.001) and 70% reduction in heart failure alone (hazard ratio: 0.30, p <0.001). Women had a significant 72% reduction in all-cause mortality in the total population (hazard ratio: 0.28, p = 0.02) and significant 82% and 78% reductions in mortality in those with QRS

Original languageEnglish
Pages (from-to)813-820
Number of pages8
JournalJournal of the American College of Cardiology
Volume57
Issue number7
DOIs
Publication statusPublished - Feb 15 2011

Keywords

  • cardiac resynchronization therapy
  • MADIT-CRT
  • women

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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