TY - JOUR
T1 - Cardiac resynchronization therapy is more effective in women than in men
T2 - The MADIT-CRT (multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy) trial
AU - Arshad, Aysha
AU - Moss, Arthur J.
AU - Foster, Elyse
AU - Padeletti, Luigi
AU - Barsheshet, Alon
AU - Goldenberg, Ilan
AU - Greenberg, Henry
AU - Hall, W. Jackson
AU - McNitt, Scott
AU - Zareba, Wojciech
AU - Solomon, Scott
AU - Steinberg, Jonathan S.
PY - 2011/2/15
Y1 - 2011/2/15
N2 - Objectives: The purpose of this study was to investigate the factors related to sex-specific outcomes for death and heart failure events in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) trial. Background: In the MADIT-CRT trial, women seemed to achieve a better result from resynchronization therapy than men. Methods: All 1,820 patients (453 female and 1,367 male) enrolled in the MADIT-CRT trial were included in this sex-specific outcome analysis that compared the effect of cardiac resynchronization therapy with defibrillator (CRT-D) relative to implanted cardioverter-defibrillator (ICD) on death or heart failure (whichever came first), heart failure only, and death at any time. Results: Female patients were more likely to have nonischemic cardiomyopathy and left bundle branch block and less likely to have renal dysfunction than male patients. Overall, female patients had a better result from CRT-D therapy than male patients, with a significant 69% reduction in death or heart failure (hazard ratio: 0.31, p <0.001) and 70% reduction in heart failure alone (hazard ratio: 0.30, p <0.001). Women had a significant 72% reduction in all-cause mortality in the total population (hazard ratio: 0.28, p = 0.02) and significant 82% and 78% reductions in mortality in those with QRS
AB - Objectives: The purpose of this study was to investigate the factors related to sex-specific outcomes for death and heart failure events in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) trial. Background: In the MADIT-CRT trial, women seemed to achieve a better result from resynchronization therapy than men. Methods: All 1,820 patients (453 female and 1,367 male) enrolled in the MADIT-CRT trial were included in this sex-specific outcome analysis that compared the effect of cardiac resynchronization therapy with defibrillator (CRT-D) relative to implanted cardioverter-defibrillator (ICD) on death or heart failure (whichever came first), heart failure only, and death at any time. Results: Female patients were more likely to have nonischemic cardiomyopathy and left bundle branch block and less likely to have renal dysfunction than male patients. Overall, female patients had a better result from CRT-D therapy than male patients, with a significant 69% reduction in death or heart failure (hazard ratio: 0.31, p <0.001) and 70% reduction in heart failure alone (hazard ratio: 0.30, p <0.001). Women had a significant 72% reduction in all-cause mortality in the total population (hazard ratio: 0.28, p = 0.02) and significant 82% and 78% reductions in mortality in those with QRS
KW - cardiac resynchronization therapy
KW - MADIT-CRT
KW - women
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U2 - 10.1016/j.jacc.2010.06.061
DO - 10.1016/j.jacc.2010.06.061
M3 - Article
C2 - 21310317
AN - SCOPUS:79851471102
VL - 57
SP - 813
EP - 820
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 7
ER -