Cardiac Resynchronization Therapy MOdular REgistry: ECG and Rx predictors of response to cardiac resynchronization therapy (NCT01573091)

Giuseppe Stabile, Emanuele Bertaglia, Gianluca Botto, Francesco Isola, Giosuè Mascioli, Patrizia Pepi, Salvatore I. Caico, Antonio De Simone, Antonio D'Onofrio, Domenico Pecora, Pietro Palmisano, Giampiero Maglia, Giuseppe Arena, Maurizio Malacrida, Luigi Padeletti

Research output: Contribution to journalArticlepeer-review

Abstract

Aims A variable proportion, up to 30%, of patients who undergo cardiac resynchronization therapy (CRT) do not benefit from treatment. The aim of the Cardiac Resynchronization Therapy MOdular REgistry (CRT MORE) is to determine whether specific electrocardiographic and radiographic parameters can be used to predict clinical and echocardiographic response to CRT. Methods The CRT MORE is a prospective, single-arm, multicenter cohort study designed to evaluate the electrocardiographic and radiographic predictors of response to CRT. All study patients receive a pacemaker or implantable defibrillator for CRT delivery in accordance with current guidelines. Enrolment started in December 2011 and is scheduled to end in November 2013. Approximately 1100 consecutive patients will be enrolled in 30 Italian centers and will be followed up for 60 months after implantation. The primary endpoint is the improvement in clinical (Clinical Composite Score) and echocardiographic (a decrease of ≥15% in left ventricular end-systolic volume) parameters at the 6-month follow-up visit. Conclusion This study might provide important information about which electrocardiographic and radiographic parameters better predict CRT response.

Original languageEnglish
Pages (from-to)886-893
Number of pages8
JournalJournal of Cardiovascular Medicine
Volume14
Issue number12
DOIs
Publication statusPublished - Dec 2013

Keywords

  • Cardiac resynchronization therapy
  • ECG
  • Radiographic
  • Trial

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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