La terapia cellulare cardiaca nel trattamento dei pazienti con angina cronica refrattaria alle terapie convenzionali. Excursus sullo stato dell'arte e descrizione dell'esperienza clinica in corso all'Ospedale San Raffaele di Milano

Translated title of the contribution: Cardiac stem cell therapy for the treatment of patients with chronic stable angina refractory to conventional therapy. Digression on the state of the art and description of the ongoing clinical experience at the San Raffaele Hospital in Milan

Cosmo Godino, Carlo Briguori, Flavio Airoldi, Patrizia Toia, Marta Saolini, Angela Ferrari, Michela Cera, Gabriele Fragasso, Maria A. Imro, Monica Salomoni, Paola Todeschini, Ana M. Samanes Gajate, Luigi Gianolli, Michele Oppizzi, Maurizio C. Capogrossi, Gianluigi Condorelli, Antonio Colombo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background. Cardiac stem cell therapy is a field of scientific research with the goal to translate into clinical benefit the initial findings obtained in basic research laboratories. We have moved into clinical trials in different disease categories: acute myocardial infarction, chronic stable angina refractory to conventional therapy and heart failure. So far we have faced with contradictory results. Some previous studies suggested that bone marrow cell injection may improve myocardial perfusion and left ventricular function in patients with chronic myocardial ischemia. Methods. In this paper we present a brief review about stem cell use in clinical cardiology and describe our research protocol evaluating the effects of direct intramyocardial injection of autologous bone marrow cells (CD34+ selected cells versus all mononuclear cells) in patients with chronic myocardial ischemia. Results. Preliminary results show that this procedure seems to be safe and generally well tolerated by patients. An improvement in symptoms, in the first 6 months, appears to be achieved in approximately 50% of patients, with concomitant improvement of quantitative scintigraphic stress test imaging. Conclusions. Before drawing any definitive conclusions, we need to wait for the end of enrollment and unblinding of study randomization.

Original languageItalian
Pages (from-to)198-211
Number of pages14
JournalGiornale Italiano di Cardiologia
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Stable Angina
Cell- and Tissue-Based Therapy
Stem Cells
Bone Marrow Cells
Myocardial Ischemia
Research
Injections
Acute Disease
Therapeutics
Random Allocation
Cardiology
Exercise Test
Left Ventricular Function
Heart Failure
Perfusion
Myocardial Infarction
Clinical Trials

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

La terapia cellulare cardiaca nel trattamento dei pazienti con angina cronica refrattaria alle terapie convenzionali. Excursus sullo stato dell'arte e descrizione dell'esperienza clinica in corso all'Ospedale San Raffaele di Milano. / Godino, Cosmo; Briguori, Carlo; Airoldi, Flavio; Toia, Patrizia; Saolini, Marta; Ferrari, Angela; Cera, Michela; Fragasso, Gabriele; Imro, Maria A.; Salomoni, Monica; Todeschini, Paola; Samanes Gajate, Ana M.; Gianolli, Luigi; Oppizzi, Michele; Capogrossi, Maurizio C.; Condorelli, Gianluigi; Colombo, Antonio.

In: Giornale Italiano di Cardiologia, Vol. 12, No. 3, 03.2011, p. 198-211.

Research output: Contribution to journalArticle

Godino, Cosmo ; Briguori, Carlo ; Airoldi, Flavio ; Toia, Patrizia ; Saolini, Marta ; Ferrari, Angela ; Cera, Michela ; Fragasso, Gabriele ; Imro, Maria A. ; Salomoni, Monica ; Todeschini, Paola ; Samanes Gajate, Ana M. ; Gianolli, Luigi ; Oppizzi, Michele ; Capogrossi, Maurizio C. ; Condorelli, Gianluigi ; Colombo, Antonio. / La terapia cellulare cardiaca nel trattamento dei pazienti con angina cronica refrattaria alle terapie convenzionali. Excursus sullo stato dell'arte e descrizione dell'esperienza clinica in corso all'Ospedale San Raffaele di Milano. In: Giornale Italiano di Cardiologia. 2011 ; Vol. 12, No. 3. pp. 198-211.
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