Abstract
Recent data indicate that the heart is a self-renewing organ and contains a pool of progenitor cells (PCs). According to the new paradigm, this resident population of multipotent undifferentiated cells gives rise to myocytes, endothelial cells, smooth muscle cells and fibroblasts. Understanding the function of cardiac PCs is critical for the implementation of these cells in the treatment of the diseased human heart. However, cardiac repair is an extremely complex phenomenon. Efficient myocardial regeneration requires restoration of segmental and focal areas of myocardial scarring, replacement of damaged coronary arteries, arterioles and capillaries, and substitution of hypertrophied poorly contracting myocytes with smaller better functioning parenchymal cells. To achieve these goals, the acquisition of a more profound knowledge of the biology of cardiac PCs cells and their fate following pathologic insults represents an essential need.
| Original language | English |
|---|---|
| Pages (from-to) | 505-513 |
| Number of pages | 9 |
| Journal | Journal of Molecular and Cellular Cardiology |
| Volume | 45 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 2008 |
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Keywords
- Cardiac aging
- Diabetic cardiomyopathy
- Heart failure
- Stem cells
ASJC Scopus subject areas
- Molecular Biology
- Cardiology and Cardiovascular Medicine
Cite this
Cardiac stem cells and myocardial disease. / Kajstura, Jan; Urbanek, Konrad; Rota, Marcello; Bearzi, Claudia; Hosoda, Toru; Bolli, Roberto; Anversa, Piero; Leri, Annarosa.
In: Journal of Molecular and Cellular Cardiology, Vol. 45, No. 4, 10.2008, p. 505-513.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiac stem cells and myocardial disease
AU - Kajstura, Jan
AU - Urbanek, Konrad
AU - Rota, Marcello
AU - Bearzi, Claudia
AU - Hosoda, Toru
AU - Bolli, Roberto
AU - Anversa, Piero
AU - Leri, Annarosa
PY - 2008/10
Y1 - 2008/10
N2 - Recent data indicate that the heart is a self-renewing organ and contains a pool of progenitor cells (PCs). According to the new paradigm, this resident population of multipotent undifferentiated cells gives rise to myocytes, endothelial cells, smooth muscle cells and fibroblasts. Understanding the function of cardiac PCs is critical for the implementation of these cells in the treatment of the diseased human heart. However, cardiac repair is an extremely complex phenomenon. Efficient myocardial regeneration requires restoration of segmental and focal areas of myocardial scarring, replacement of damaged coronary arteries, arterioles and capillaries, and substitution of hypertrophied poorly contracting myocytes with smaller better functioning parenchymal cells. To achieve these goals, the acquisition of a more profound knowledge of the biology of cardiac PCs cells and their fate following pathologic insults represents an essential need.
AB - Recent data indicate that the heart is a self-renewing organ and contains a pool of progenitor cells (PCs). According to the new paradigm, this resident population of multipotent undifferentiated cells gives rise to myocytes, endothelial cells, smooth muscle cells and fibroblasts. Understanding the function of cardiac PCs is critical for the implementation of these cells in the treatment of the diseased human heart. However, cardiac repair is an extremely complex phenomenon. Efficient myocardial regeneration requires restoration of segmental and focal areas of myocardial scarring, replacement of damaged coronary arteries, arterioles and capillaries, and substitution of hypertrophied poorly contracting myocytes with smaller better functioning parenchymal cells. To achieve these goals, the acquisition of a more profound knowledge of the biology of cardiac PCs cells and their fate following pathologic insults represents an essential need.
KW - Cardiac aging
KW - Diabetic cardiomyopathy
KW - Heart failure
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=54149095610&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54149095610&partnerID=8YFLogxK
U2 - 10.1016/j.yjmcc.2008.05.025
DO - 10.1016/j.yjmcc.2008.05.025
M3 - Article
C2 - 18598700
AN - SCOPUS:54149095610
VL - 45
SP - 505
EP - 513
JO - Journal of Molecular and Cellular Cardiology
JF - Journal of Molecular and Cellular Cardiology
SN - 0022-2828
IS - 4
ER -