Cardiac stem cells: Isolation, expansion and experimental use for myocardial regeneration

Lucio Barile, Isotta Chimenti, Roberto Gaetani, Elvira Forte, Fabio Miraldi, Giacomo Frati, Elisa Messina, Alessandro Giacomello

Research output: Contribution to journalArticle

Abstract

Cellular cardiomyoplasty (myogenic cell grafting) is actively being explored as a novel method to regenerate damaged myocardium. The adult human heart contains small populations of indigenous committed cardiac stem cells or multipotent cardiac progenitor cells, identified by their cell-surface expression of c-kit (the receptor for stem cell factor), P-glycoprotein (a member of the multidrug resistance protein family), and Sca-1 (stem cell antigen 1, a mouse hematopoietic stem cell marker) or a Sca-1-like protein. Cardiac stem cells represent a logical source to exploit in cardiac regeneration therapy because, unlike other adult stem cells, they are likely to be intrinsically programmed to generate cardiac tissue in vitro and to increase cardiac tissue viability in vitro. Cardiac stem cell therapy could, therefore, change the fundamental approach to the treatment of heart disease.

Original languageEnglish
JournalNature Clinical Practice Cardiovascular Medicine
Volume4
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Feb 2007

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Cell Separation
Regeneration
Stem Cells
Cardiomyoplasty
Proto-Oncogene Proteins c-kit
Multipotent Stem Cells
P-Glycoproteins
Tissue Survival
Adult Stem Cells
Stem Cell Factor
P-Glycoprotein
Cell- and Tissue-Based Therapy
Hematopoietic Stem Cells
Population Groups
Heart Diseases
Myocardium
Therapeutics
Proteins
In Vitro Techniques

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cardiac stem cells : Isolation, expansion and experimental use for myocardial regeneration. / Barile, Lucio; Chimenti, Isotta; Gaetani, Roberto; Forte, Elvira; Miraldi, Fabio; Frati, Giacomo; Messina, Elisa; Giacomello, Alessandro.

In: Nature Clinical Practice Cardiovascular Medicine, Vol. 4, No. SUPPL. 1, 02.2007.

Research output: Contribution to journalArticle

Barile, Lucio ; Chimenti, Isotta ; Gaetani, Roberto ; Forte, Elvira ; Miraldi, Fabio ; Frati, Giacomo ; Messina, Elisa ; Giacomello, Alessandro. / Cardiac stem cells : Isolation, expansion and experimental use for myocardial regeneration. In: Nature Clinical Practice Cardiovascular Medicine. 2007 ; Vol. 4, No. SUPPL. 1.
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