Cardiac Syndrome X and Microvascular Angina

Gaetano A. Lanza, Rossella Parrinello, Stefano Figliozzi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cardiac syndrome X is defined as the occurrence of typical chest pain and evidence of myocardial ischemia on noninvasive stress tests (mainly, ST-segment depression during exercise stress test), in the presence of normal coronary arteries at angiography and in the absence of any other cardiac diseases. This condition is now mainly defined as primary microvascular angina (MVA). Abnormalities of endothelium-dependent and endothelium-independent coronary microvascular dilation have been described in many studies, using different invasive and noninvasive methods. An increased coronary microvascular constriction is also involved. The causes of the coronary microvascular dysfunction are likely multiple and may include common cardiovascular risk factors, an abnormal cardiac adrenergic function, insulin resistance, inflammation and, in women, estrogen deficiency. Prognosis is good, but quality of life can significantly be impaired in 10–20 % of patients. Treatment includes classical anti-ischemic drugs and several other pharmacological and nonpharmacological therapeutic tools for those with symptoms refractory to standard antianginal and anti-ischemic therapy.

Original languageEnglish
Title of host publicationPanVascular Medicine, Second Edition
PublisherSpringer Berlin Heidelberg
Pages1845-1864
Number of pages20
ISBN (Print)9783642370786, 9783642370779
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Microvascular Angina
Exercise Test
Endothelium
Angiography
Adrenergic Agents
Refractory materials
Estrogens
Insulin
Chest Pain
Constriction
Myocardial Ischemia
Insulin Resistance
Dilatation
Heart Diseases
Coronary Vessels
Therapeutics
Quality of Life
Pharmaceutical Preparations
Pharmacology
Inflammation

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lanza, G. A., Parrinello, R., & Figliozzi, S. (2015). Cardiac Syndrome X and Microvascular Angina. In PanVascular Medicine, Second Edition (pp. 1845-1864). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-37078-6_61

Cardiac Syndrome X and Microvascular Angina. / Lanza, Gaetano A.; Parrinello, Rossella; Figliozzi, Stefano.

PanVascular Medicine, Second Edition. Springer Berlin Heidelberg, 2015. p. 1845-1864.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lanza, GA, Parrinello, R & Figliozzi, S 2015, Cardiac Syndrome X and Microvascular Angina. in PanVascular Medicine, Second Edition. Springer Berlin Heidelberg, pp. 1845-1864. https://doi.org/10.1007/978-3-642-37078-6_61
Lanza GA, Parrinello R, Figliozzi S. Cardiac Syndrome X and Microvascular Angina. In PanVascular Medicine, Second Edition. Springer Berlin Heidelberg. 2015. p. 1845-1864 https://doi.org/10.1007/978-3-642-37078-6_61
Lanza, Gaetano A. ; Parrinello, Rossella ; Figliozzi, Stefano. / Cardiac Syndrome X and Microvascular Angina. PanVascular Medicine, Second Edition. Springer Berlin Heidelberg, 2015. pp. 1845-1864
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